Angiogenesis Inhibition in Prostate Cancer: An Update

Prostate cancer (PCa), like all other solid tumors, relies on angiogenesis for growth, progression, and the dissemination of tumor cells to other parts of the body. Despite data from in vitro and in vivo preclinical studies, as well as human specimen studies indicating the crucial role played by ang...

Full description

Saved in:

Bibliographic Details
Published in:	Cancers 2020-09, Vol.12 (9), p.2382
Main Authors:	Sarkar, Chandrani, Goswami, Sandeep, Basu, Sujit, Chakroborty, Debanjan
Format:	Article
Language:	eng
Subjects:	Androgens Angiogenesis angiogenic growth factors Antiangiogenic agents antiangiogenic therapy Binding sites Blood platelets Cancer therapies Clinical trials Disease Fibroblasts Growth factors Kinases Metastasis Patients Physiological aspects Physiology Prostate cancer Review Roles Solid tumors Tumor cells Tumor necrosis factor-TNF Tumors Vascular endothelial growth factor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Prostate cancer (PCa), like all other solid tumors, relies on angiogenesis for growth, progression, and the dissemination of tumor cells to other parts of the body. Despite data from in vitro and in vivo preclinical studies, as well as human specimen studies indicating the crucial role played by angiogenesis in PCa, angiogenesis inhibition in clinical settings has not shown significant benefits to patients, thus challenging the inclusion and usefulness of antiangiogenic agents for the treatment of PCa. However, one of the apparent reasons why these antiangiogenic agents failed to meet expectations in PCa can be due to the choice of the antiangiogenic agents, because the majority of these drugs target vascular endothelial growth factor-A (VEGFA) and its receptors. The other relevant causes might be inappropriate drug combinations, the duration of treatment, and the method of endpoint determination. In this review, we will first discuss the role of angiogenesis in PCa growth and progression. We will then summarize the different angiogenic growth factors that influence PCa growth dynamics and review the outcomes of clinical trials conducted with antiangiogenic agents in PCa patients and, finally, critically assess the current status and fate of antiangiogenic therapy in this disease.
ISSN:	2072-6694 2072-6694