High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance

High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance is largely unknown. Here, we show that lean mice become insulin resistant after being administered exosomes isolated from the feces of obese mice fed a HFD or from patients with type II diabetes. HFD alter...

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Bibliographic Details

Published in:	Nature communications 2021-01, Vol.12 (1), p.213-21, Article 213
Main Authors:	Kumar, Anil, Sundaram, Kumaran, Mu, Jingyao, Dryden, Gerald W, Sriwastva, Mukesh K, Lei, Chao, Zhang, Lifeng, Qiu, Xiaolan, Xu, Fangyi, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Bohler, Henry C L, Wang, Baomei, Zhang, Shuangqin, Qin, Chao, Xu, Ziying, Han, Xianlin, McClain, Craig J, Teng, Yun, Zhang, Huang-Ge
Format:	Article
Language:	eng
Subjects:	1-Phosphatidylinositol 3-kinase Adipose Tissue - metabolism AKT protein Animals Aromatic compounds Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diet Diet, High-Fat Downstream effects Dyslipidemias - complications Dyslipidemias - genetics Dyslipidemias - pathology Epithelial Cells - metabolism Exosomes Exosomes - metabolism Fatty Liver - complications Fatty Liver - genetics Fatty Liver - pathology Feces Gene expression Gene Expression Regulation Genes Glucose Intolerance Green Fluorescent Proteins - metabolism Hepatocytes High fat diet Humans Insulin Insulin - metabolism Insulin resistance Insulin Resistance - genetics Interleukin-6 - blood Intestine Intestines - cytology Lecithin Lipid composition Lipids Lipids - chemistry Liver - metabolism Liver - pathology Macrophage Activation Macrophages Mice Mice, Inbred C57BL Phosphatidylcholine Phosphatidylcholines - metabolism Phosphatidylethanolamine Receptors, Aryl Hydrocarbon - metabolism Signal Transduction Signaling Tetraspanin 30 - metabolism Transcription activation Tumor Necrosis Factor-alpha - blood Up-Regulation - genetics
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