Electrolyte Disturbances in SARS-CoV-2 Infection [version 2; peer review: 2 approved]

Electrolyte Disturbances in SARS-CoV-2 Infection [version 2; peer review: 2 approved]

The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to unprecedented global morbidity and mortality. With a bewildering array of complications, renal involvement in various forms is common, including serum electrolyte derangements. Hypokalaemi...

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Bibliographic Details
Published in:F1000 research 2020, Vol.9, p.587-587
Main Authors: Mabillard, Holly, Sayer, John A
Format: Article
Language:eng
Subjects:
Aldosterone
Angiotensin
Binding sites
Blood pressure
Cardiovascular disease
Coronaviruses
COVID-19
Creatinine
Diabetes
Diarrhea
Disease transmission
Dyspnea
Electrolytes
Guillain-Barre syndrome
Hypertension
Hypokalemia
Infections
Kidney diseases
Laboratories
Morbidity
Opinion
Pandemics
Patients
Potassium
Renin
Severe acute respiratory syndrome coronavirus 2
Urine
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Summary:The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to unprecedented global morbidity and mortality. With a bewildering array of complications, renal involvement in various forms is common, including serum electrolyte derangements. Hypokalaemia secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and histopathological data and important clinical implications. Mechanisms of hypokalaemia are multifactorial and so the electrolyte disturbance can be difficult to avoid. We provide further support to the theory of renin-angiotensin-aldosterone (RAS) activation, discuss the strengths and weaknesses of implicating RAS involvement and highlight the importance of calculating the transtubular potassium gradient to identify those at risk of hypokalaemia and its complications.
ISSN:2046-1402
2046-1402