Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis
Enterococcus faecalis ( E. faecalis ), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic...
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Published in: | Frontiers in microbiology 2019-10, Vol.10, p.2301-2301 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | Enterococcus faecalis
(
E. faecalis
), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound CD437 was found to have potent bactericidal effect on
E. faecalis
. In addition, CD437 exhibited synergistic effects when administered in combination with gentamicin and additive effects when combined with ceftriaxone sodium. CD437 also inhibited biofilm formation by
E. faecalis
and exerted bactericidal effect on mature biofilm. Moreover, CD437 exhibited antibacterial and anti-biofilm effects against
Staphylococcus
. No bactericidal action of CD437 was observed against the gram-negative bacillus, but
Pseudomonas aeruginosa
biofilm extracellular polymeric substances (EPS) matrix formation was reduced. Overall, these findings indicate that CD437 has the potential to be developed as a novel antibacterial drug. |
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ISSN: | 1664-302X 1664-302X |