Indocyanine green lymphangiography is superior to clinical staging in breast cancer-related lymphedema

Precise staging of breast cancer-related lymphedema (BCRL) is important to guide treatment-decision making. Recent studies have suggested staging of BCRL using indocyanine green lymphangiography (ICG-L) based on the extent of lymphatic injury and dermal backflow patterns. Currently, the benefits of...

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Published in:	Scientific reports 2021-10, Vol.11 (1), p.21103-21103, Article 21103
Main Authors:	Jørgensen, Mads Gustaf, Hermann, Anne Pernille, Madsen, Anette Riis, Christensen, Steffanie, Sørensen, Jens Ahm
Format:	Article
Language:	eng
Subjects:	Absorptiometry, Photon Aged Body fat Breast cancer Breast Cancer Lymphedema - diagnostic imaging Breast Neoplasms - diagnostic imaging Decision making Dual energy X-ray absorptiometry Female Humans Indocyanine Green - administration & dosage Lymphangiography Lymphedema Lymphography Middle Aged Patients Regression analysis Statistical analysis
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Summary:	Precise staging of breast cancer-related lymphedema (BCRL) is important to guide treatment-decision making. Recent studies have suggested staging of BCRL using indocyanine green lymphangiography (ICG-L) based on the extent of lymphatic injury and dermal backflow patterns. Currently, the benefits of ICG-L compared to conventional clinical staging are unknown. For this study, we included 200 patients with unilateral BCRL. All BCRL patients were staged using ICG-L and clinical exam. The amounts of excess arm volume, fat mass and lean mass were compared between stages using Dual Energy X-Ray Absorptiometry. Multivariate regression models were used to adjust for confounders. For each increase in the patient's ICG-L stage, the excess arm volume, fat mass and lean mass was increased by 8, 12 and 6.5 percentage points respectively (P
ISSN:	2045-2322 2045-2322