Maternal paraben exposure triggers childhood overweight development

Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects has been discussed controversially in recent years. Here we investigate the effect of prenatal paraben exposure on childhood overweight by comb...

Full description

Saved in:

Bibliographic Details
Published in:	Nature communications 2020-02, Vol.11 (1), p.561-12, Article 561
Main Authors:	Leppert, Beate, Strunz, Sandra, Seiwert, Bettina, Schlittenbauer, Linda, Schlichting, Rita, Pfeiffer, Christiane, Röder, Stefan, Bauer, Mario, Borte, Michael, Stangl, Gabriele I, Schöneberg, Torsten, Schulz, Angela, Karkossa, Isabell, Rolle-Kampczyk, Ulrike E, Thürmann, Loreen, von Bergen, Martin, Escher, Beate I, Junge, Kristin M, Reemtsma, Thorsten, Lehmann, Irina, Polte, Tobias
Format:	Article
Language:	eng
Subjects:	Animals Appetite Body weight Body weight gain Child Child, Preschool Children Consumer products Cosmetics Eating Epidemiology Exposure Female Food Food intake Health risks Humans Hypothalamus Hypothalamus - metabolism Male Maternal Exposure - adverse effects Mice Mice, Inbred C57BL Offspring Overweight - etiology Overweight - genetics Overweight - metabolism Overweight - physiopathology Parabens - adverse effects Parabens - analysis Pregnancy Prenatal experience Prenatal Exposure Delayed Effects - etiology Prenatal Exposure Delayed Effects - genetics Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - physiopathology Preservatives Preservatives, Pharmaceutical - adverse effects Preservatives, Pharmaceutical - analysis Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Proopiomelanocortin Urine - chemistry Weight Gain
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects has been discussed controversially in recent years. Here we investigate the effect of prenatal paraben exposure on childhood overweight by combining epidemiological data from a mother-child cohort with experimental approaches. Mothers reporting the use of paraben-containing cosmetic products have elevated urinary paraben concentrations. For butyl paraben (BuP) a positive association is observed to overweight within the first eight years of life with a stronger trend in girls. Consistently, maternal BuP exposure of mice induces a higher food intake and weight gain in female offspring. The effect is accompanied by an epigenetic modification in the neuronal Pro-opiomelanocortin (POMC) enhancer 1 leading to a reduced hypothalamic POMC expression. Here we report that maternal paraben exposure may contribute to childhood overweight development by altered POMC-mediated neuronal appetite regulation.
ISSN:	2041-1723 2041-1723