Adipose-derived stem cells for treatment of chronic ulcers: current status

Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summari...

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Bibliographic Details
Published in:	Stem cell research & therapy 2018-05, Vol.9 (1), p.142-142, Article 142
Main Authors:	Holm, Jens Selch, Toyserkani, Navid Mohamadpour, Sorensen, Jens Ahm
Format:	Article
Language:	eng
Subjects:	Adipose tissues Adipose-derived stem cells Analysis Care and treatment Chronic Disease Chronic ulcers Chronic wounds Clinical trials Health aspects Humans Mesenchymal Stem Cells - physiology Review Stem cells Stromal vascular fraction Ulcer - pathology Ulcer - therapy Ulcers Wound Healing
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Summary:	Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summarize the current status of treating chronic ulcers with ADSC, this systematic review includes all clinical trials on the subject from PubMed and EmBase, as well as all registered clinical trials on ClinicalTrials.Gov. A total of nine clinical trials and fourteen registered trials were included. The studies were significantly different in terms of study design and patient population, and the overall quality of the studies was low to moderate. Despite the overall low study quality and the significant differences between the studies, some conclusions were consistent: ADSCs are safe, improve the healing of chronic ulcers, and reduce pain. As these results are consistent despite the shortcomings of the studies, they appear to highlight the efficacy of ADSCs in the treatment of chronic ulcers. Larger numbers of higher quality studies are needed to determine the precise role of ADSCs in treating chronic leg ulcers.
ISSN:	1757-6512 1757-6512