Immunoglobulin A as a Key Immunological Molecular Signature of Post-COVID-19 Conditions

COVID-19 has infected humans worldwide, causing millions of deaths or prolonged symptoms in survivors. The transient or persistent symptoms after SARS-CoV-2 infection have been defined as post-COVID-19 conditions (PCC). We conducted a study of 151 Brazilian PCC patients to analyze symptoms and immun...

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Bibliographic Details
Published in:Viruses 2023-07, Vol.15 (7), p.1545
Main Authors: Sousa, Graziele F, Carpes, Raphael M, Silva, Carina A O, Pereira, Marcela E P, Silva, Amanda C V F, Coelho, Viktoria A G S, Costa, Evenilton P, Mury, Flávia B, Gestinari, Raquel S, Souza-Menezes, Jackson, Leal-da-Silva, Manuela, Nepomuceno-Silva, José L, Tanuri, Amilcar, Ferreira-Júnior, Orlando C, Monteiro-de-Barros, Cintia
Format: Article
Language:English
Subjects:
Antibodies
Anxiety
Comorbidity
COVID-19
COVID-19 vaccines
Health aspects
Hospitalization
Immunization
Immunoglobulin A
immunoglobulin profiles
Immunoglobulins
Immunology
Infections
Memory
Myalgia
Olfaction disorders
Pandemics
Patients
Physiological aspects
post-COVID-19 conditions
SARS-CoV-2
Serology
Severe acute respiratory syndrome coronavirus 2
Software
Taste disorders
Vaccination
Womens health
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Summary:COVID-19 has infected humans worldwide, causing millions of deaths or prolonged symptoms in survivors. The transient or persistent symptoms after SARS-CoV-2 infection have been defined as post-COVID-19 conditions (PCC). We conducted a study of 151 Brazilian PCC patients to analyze symptoms and immunoglobulin profiles, taking into account sex, vaccination, hospitalization, and age. Fatigue and myalgia were the most common symptoms, and lack of vaccination, hospitalization, and neuropsychiatric and metabolic comorbidities were relevant to the development of PCC. Analysis of serological immunoglobulins showed that IgA was higher in PCC patients, especially in the adult and elderly groups. Also, non-hospitalized and hospitalized PCC patients produced high and similar levels of IgA. Our results indicated that the detection of IgA antibodies against SARS-CoV-2 during the course of the disease could be associated with the development of PCC and may be an immunological signature to predict prolonged symptoms in COVID-19 patients.
ISSN:1999-4915
1999-4915
DOI:10.3390/v15071545