Adamantane-resistant influenza infection during the 2004-05 season

Adamantane-resistant influenza A is an emerging problem, but infections caused by resistant and susceptible viruses have not been compared. We identified adamantane resistance in 47% of 152 influenza A virus (H3N2) isolates collected during 2005. Resistant and susceptible viruses caused similar symp...

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Bibliographic Details
Published in:Emerging infectious diseases 2008-01, Vol.14 (1), p.173-176
Main Authors: Rahman, Mahbubur, Bright, Rick A, Kieke, Burney A, Donahue, James G, Greenlee, Robert T, Vandermause, Mary, Balish, Amanda, Foust, Angela, Cox, Nancy J, Klimov, Alexander I, Shay, David K, Belongia, Edward A
Format: Article
Language:English
Subjects:
Adamantane - therapeutic use
Adamantane resistance
Adolescent
Adult
Aged
Antiviral agents
Antiviral Agents - therapeutic use
Child
Child, Preschool
clinical feature
Cohort Studies
Disease Outbreaks
Dispatch
Drug Resistance, Viral - genetics
Female
Health aspects
Humans
Infant
Influenza
Influenza A virus
Influenza A Virus, H3N2 Subtype - drug effects
Influenza A Virus, H3N2 Subtype - genetics
Influenza A Virus, H3N2 Subtype - isolation & purification
Influenza B virus - drug effects
Influenza, Human - drug therapy
Influenza, Human - epidemiology
Influenza, Human - genetics
Male
Middle Aged
Prevalence studies (Epidemiology)
Structure-activity relationships
United States
Wisconsin - epidemiology
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Description
Summary:Adamantane-resistant influenza A is an emerging problem, but infections caused by resistant and susceptible viruses have not been compared. We identified adamantane resistance in 47% of 152 influenza A virus (H3N2) isolates collected during 2005. Resistant and susceptible viruses caused similar symptoms and illness duration. The prevalence of resistance was highest in children.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1401.070460