Dataset related to article "The impact of biologic therapy for moderate-to-severe psoriasis on the immune responses to SARS-CoV-2 infection and vaccination"

Dataset related to article "The impact of biologic therapy for moderate-to-severe psoriasis on the immune responses to SARS-CoV-2 infection and vaccination" In our study we explored the impact of biologics and conventional therapies on humoral and T-cellular responses to SARS-CoV-2 infecti...

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Main Authors: Favaro, Rebecca, Formai, Alessandra, Pavia, Giulia, Gargiulo, Luigi, Avagliano, Jessica, Valenti, Mario, Facheris, Paola, Salsano, Beatrice, Latorre, Roberta Valeria, Bellinato, Francesco, GISONDI, Paolo, NARCISI, ALESSANDRA, Costanzo, Antonio
Format: Dataset
Language:English
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Summary:Dataset related to article "The impact of biologic therapy for moderate-to-severe psoriasis on the immune responses to SARS-CoV-2 infection and vaccination" In our study we explored the impact of biologics and conventional therapies on humoral and T-cellular responses to SARS-CoV-2 infection and vaccine, comparing the results with the healthy donors’ immune responses. The main findings of our study are that while biologic therapy for moderate-to-severe psoriasis with anti-IL23 and IL-17 has no significant effect on the humoral and T-cell mediated immune response; in contrast, conventional therapies and TNF-a blockade reduce the production of specific antibodies. Moreover, our results suggest that treatment with anti-IL-23 can enhance anti-covid responses induced by the vaccine since we found higher antibody levels in vaccinated patients treated with IL-23 inhibitors with an effect on follicular T helper cells.
ISSN:0007-0963
DOI:10.5281/zenodo.10579696