DNA gel particles: An overview

A general understanding of interactions between DNA and oppositely charged compounds forms the basis for developing novel DNA-based materials, including gel particles. The association strength, which is altered by varying the chemical structure of the cationic cosolute, determines the spatial homoge...

Full description

Saved in:
Bibliographic Details
Published in:Advances in colloid and interface science 2014-03, Vol.205, p.240-256
Main Authors: Morán, M. Carmen, Vinardell, M. Pilar, Infante, M. Rosa, Miguel, M. Graça, Lindman, Björn
Format: Article
Language:English
Subjects:
ADN
Agents tensioactius
Animals
Assessments
Biocompatible Materials - chemistry
Biological and medical sciences
Biotechnology
Cationic
Colloids in medicine
Col·loides en medicina
Cytotoxicity
Deoxyribonucleic acid
Devices
DNA
DNA - chemistry
DNA gels
DNA release
DNA–oppositely charged agent interaction
Drug delivery systems
Entrapment
Fundamental and applied biological sciences. Psychology
Gels - chemistry
Health. Pharmaceutical industry
Hemocompatibility
Homogeneity
Humans
Hydrophobicity
Industrial applications and implications. Economical aspects
Materials nanoestructurats
Nanoparticles
Nanopartícules
Nanostructured materials
Particle Size
Particles
Polymers
Polímers
Sistemes d'alliberament de medicaments
Surface active agents
Surface Properties
Swelling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A general understanding of interactions between DNA and oppositely charged compounds forms the basis for developing novel DNA-based materials, including gel particles. The association strength, which is altered by varying the chemical structure of the cationic cosolute, determines the spatial homogeneity of the gelation process, creating DNA reservoir devices and DNA matrix devices that can be designed to release either single- (ssDNA) or double-stranded (dsDNA) DNA. This review covers recent developments on the topic of DNA gel particles formed in water–water emulsion-type interfaces. The degree of DNA entrapment, particle morphology, swelling/dissolution behavior and DNA release responses are discussed as functions of the nature of the cationic agent used. On the basis of designing DNA gel particles for therapeutic purposes, recent studies on the determination of the surface hydrophobicity and the hemolytic and the cytotoxic assessments of the obtained DNA gel particles have been also reported. [Display omitted] •Comprehensive review of DNA gel particles as controlled DNA delivery systems•DNA gel particles derived from surfactants, proteins and polysaccharides•Kinetics of swelling or deswelling, dissolution, and DNA release•In vitro hemolytic and cytotoxic characterization•Current status and prospects on DNA gel particles are discussed.
ISSN:0001-8686
1873-3727
DOI:10.1016/j.cis.2013.09.002