Improved classification of leukemic B-cell lymphoproliferative disorders using a transcriptional and genetic classifier

B-cell chronic lymphoproliferative disorders (B-CLPD) encompass a group of hematologic tumors that often present with leukemic involvement.1 Their heterogeneity and the lack of relatively specific diagnostic markers for most of these diseases make their diagnosis challenging, especially in cases tha...

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Bibliographic Details
Published in:Haematologica (Roma) 2017-09
Main Authors: Navarro, Alba, Clot, Guillem, Martínez Trillos, Alejandra, Pinyol, Magda, Jares Gerboles, Pedro, González Farré, Blanca, Martínez, Daniel, Trim, Nicola, Fernández, Verónica, Villamor i Casas, Neus, Colomer, Dolors, Costa, Dolors, Salaverria Frigola, Itziar, Martín Gárcia, David, Erber, Wendy, López, Cristina, Jayne, Sandrine, Siebert, Reiner, Dyer, Martin J. S, Wiestner, Adrian, Wilson, Wyndham H, Aymerich Gregorio, Marta, López Guillermo, Armando, Sánchez, Àlex, Campo Güerri, Elias, Matutes, Estella, Beà Bobet, Sílvia M
Format: Article
Language:English
Subjects:
Leucèmia
Leukemia
Tumors
Online Access:Get full text
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Summary:B-cell chronic lymphoproliferative disorders (B-CLPD) encompass a group of hematologic tumors that often present with leukemic involvement.1 Their heterogeneity and the lack of relatively specific diagnostic markers for most of these diseases make their diagnosis challenging, especially in cases that only have blood involvement or when histology is not available. With the currently used immunophenotypic and molecular markers, around 10% of B-CLPD cases remain unclassifiable and are categorized as B-CLPD, not otherwise specified (B-CLPD, NOS).
ISSN:0390-6078