Direct Laser Interference Patterning of CoCr Alloy Surfaces to Control Endothelial Cell and Platelet Response for Cardiovascular Applications

The main drawbacks of cardiovascular bare‐metal stents (BMS) are in‐stent restenosis and stent thrombosis as a result of an incomplete endothelialization after stent implantation. Nano‐ and microscale modification of implant surfaces is a strategy to recover the functionality of the artery by stimul...

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Bibliographic Details
Published in:Advanced healthcare materials 2017-10, Vol.6 (19), p.n/a
Main Authors: Schieber, Romain, Lasserre, Federico, Hans, Michael, Fernández‐Yagüe, Marc, Díaz‐Ricart, Maribel, Escolar, Ginés, Ginebra, Maria‐Pau, Mücklich, Frank, Pegueroles, Marta
Format: Article
Language:English
Subjects:
Adhesion
Biological activity
Blood platelets
Blood Platelets - cytology
Blood Platelets - physiology
Blood Vessel Prosthesis
Cell Adhesion - physiology
Cells, Cultured
Chromium
Chromium Alloys - chemistry
Chromium Alloys - radiation effects
Chromium base alloys
Cobalt
Cobalt base alloys
CoCr
Direct laser interference patterning
Elongation
Endothelial cells
Endothelial Cells - cytology
Endothelial Cells - physiology
Enginyeria biomèdica
Equipment Failure Analysis
Humans
Implantation
Implants
Interference
Lasers
Linear surface pattern
Materials Testing
Pattern formation
Plaquetes sanguínies
Platelets
Prosthesis Design
Radiation Dosage
Restenosis
Stents
Surface Properties - radiation effects
Surgical implants
Thromboembolism
Thrombosis
Umbilical vein
Wettability
Àrees temàtiques de la UPC
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Summary:The main drawbacks of cardiovascular bare‐metal stents (BMS) are in‐stent restenosis and stent thrombosis as a result of an incomplete endothelialization after stent implantation. Nano‐ and microscale modification of implant surfaces is a strategy to recover the functionality of the artery by stimulating and guiding molecular and biological processes at the implant/tissue interface. In this study, cobalt‐chromium (CoCr) alloy surfaces are modified via direct laser interference patterning (DLIP) in order to create linear patterning onto CoCr surfaces with different periodicities (≈3, 10, 20, and 32 µm) and depths (≈20 and 800 nm). Changes in surface topography, chemistry, and wettability are thoroughly characterized before and after modification. Human umbilical vein endothelial cells' adhesion and spreading are similar for all patterned and plain CoCr surfaces. Moreover, high‐depth series induce cell elongation, alignment, and migration along the patterned lines. Platelet adhesion and aggregation decrease in all patterned surfaces compared to CoCr control, which is associated with changes in wettability and oxide layer characteristics. Cellular studies provide evidence of the potential of DLIP topographies to foster endothelialization without enhancement of platelet adhesion, which will be of high importance when designing new BMS in the future. This work offers a new use of direct laser interference patterning (DLIP) technique, on cobalt‐chromium (CoCr) alloys, to obtain linear patterned and chemically modified surfaces. The obtained topography induces endothelial cell alignment and migration, and, chemical changes reduce platelet adhesion. Consequently, DLIP can be a one‐step technique to obtain surfaces with the capacity to enhance endothelialization and reduce thrombogenicity.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201700327