Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neuronal Cells from Excitotoxicity: I. Fermentation, Isolation, Physico-chemical Properties and Biological Activity

Glutamate, an excitatory amino acid, is known to induce neurotoxicity in central nervous system under abnormal conditions such as ischemia, hypoglycemia, epilepsy, Huntington's chorea, Parkinson's disease and Alzheimer's disease. In our search for neuroprotective agents of microbial o...

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Published in:Journal of antibiotics 2001/12/25, Vol.54(12), pp.1013-1018
Main Authors: KOBAYASHI, HIROYUKI, SHIN-YA, KAZUO, NAGAI, KOJI, SUZUKI, KEN-ICHI, HAYAKAWA, YOICHI, SETO, HARUO, YUN, BONG-SIK, RYOO, IN-JA, KIM, JUNG-SIK, KIM, CHANG-JIN, YOO, ICK-DONG
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cells, Cultured
Chick Embryo
Fermentation
Medical sciences
Membrane Glycoproteins - drug effects
Nerve Tissue Proteins - drug effects
Neuropharmacology
Neuroprotective agent
Neuroprotective Agents - chemistry
Neuroprotective Agents - isolation & purification
Neuroprotective Agents - pharmacology
Oligopeptides - chemistry
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Pharmacology. Drug treatments
Receptors, N-Methyl-D-Aspartate - drug effects
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Summary:Glutamate, an excitatory amino acid, is known to induce neurotoxicity in central nervous system under abnormal conditions such as ischemia, hypoglycemia, epilepsy, Huntington's chorea, Parkinson's disease and Alzheimer's disease. In our search for neuroprotective agents of microbial origin against excitatory neurotoxins, we have isolated two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound complestatin, from the fermentation broth of Streptomyces sp. Q27107. Neuroprotectins protected primary cultured chick telencephalic neurons from glutamate- and kainate-induced excitotoxicities in a dose-dependant fashion.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.1013