Assessment of insertion/deletion polymorphism of ACE gene as a genetic risk marker for preeclampsia in pregnant women

To investigate the possible associations of angiotensin converting enzyme insertion or deletion genotypes and alleles with the risk of preeclampsia in Arab women. The case-control study was conducted from January 2016 to December 2017 at King Abdulaziz University Hospital and Maternity & Childre...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2020-05, Vol.70 (5), p.791
Main Authors: Gull, Munazza, Muharram, Ebtesam Ibrahim, Shaik, Noor Ahmad, Al Mahdi, Hadiah Bassam, Bondagji, Nabeel Salem, Al Doghaither, Huda Abdulaziz
Format: Article
Language:English
Subjects:
Adult
Blood Pressure Determination - methods
Blood Pressure Determination - statistics & numerical data
Case-Control Studies
Female
Genetic Markers
Genetic Profile
Humans
Mutagenesis, Insertional
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Pre-Eclampsia - diagnosis
Pre-Eclampsia - ethnology
Pre-Eclampsia - genetics
Pregnancy
Saudi Arabia
Sequence Deletion
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Summary:To investigate the possible associations of angiotensin converting enzyme insertion or deletion genotypes and alleles with the risk of preeclampsia in Arab women. The case-control study was conducted from January 2016 to December 2017 at King Abdulaziz University Hospital and Maternity & Children Hospital, Jeddah, Saudi Arabia, and comprised pregnant women withpreeclampsia as cases and normal pregnant women as controls. Deoxyribonucleic acid was extracted and angiotensin-converting enzyme gene was amplified by polymerase chain reaction analysis and characterised through gel electrophoresis. Of the 162 women, 68(42%) were cases and 94(58%) controls. The mean values of age, body mass index, and systolic and diastolic blood pressure were significantly different among the cases than the controls (p0.05). The distribution of the polymorphic variants of the angiotensin converting enz yme gene insertion/deletion was not significantly different between the groups (p>0.05). Also, genotype distribution and allelic frequencies were not significantly different between the groups (p>0.05). For insertion/deletion polymorphism, no significant differences were detected in the genotype and allele frequencies or any of the inheritance models between preeclampsia patients and controls.
ISSN:0030-9982
DOI:10.5455/JPMA.11322