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In vitro antifungal activity of the soap formulation of the hexane leaf extract of Morinda morindoides (Morinda; Rubiaceae)
Purpose: The aim of this study was to formulate the hexane extract of the leaves of Morinda morindoides (Baker) Milne-Redh (Rubiaceae) as soap and evaluate its antifungal activity against fungal isolates of human origin. Method: The hexane extract of Morinda morindoides was incorporated as an antifu...
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Published in: | Tropical journal of pharmaceutical research 2010-12, Vol.9 (3) |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Purpose: The aim of this study was to formulate the hexane extract of
the leaves of Morinda morindoides (Baker) Milne-Redh (Rubiaceae) as
soap and evaluate its antifungal activity against fungal isolates of
human origin. Method: The hexane extract of Morinda morindoides was
incorporated as an antifungal agent in soap (SMM) and tested against 4
strains of dermatophytes ( Candida albicans , Trichophyton rubrum ,
Trichophyton mentagrophytes and Aspergillus fumigatus ) using basic
soap (BS) as control. Agar dilution method at serial concentrations
ranging from 125 mg/ml to 3.9 mg/ml was used for the determination of
the antimicrobial parameters - MIC (minimum inhibitory concentration)
and IC50 (concentration producing 50 % inhibition) for these strains.
Result: The growth of all fungal strains tested was inhibited by the
Morinda morindoides extract soap (SMM) at MIC of 31.25 mg/ml. On the
other hand, basic soap (control) inhibited Candida albicans at MIC of
125 mg/ml and at MIC of 62.50 mg/ml for the other 3 strains tested.
Thus, SMM showed stronger antifungal activity against the strains
tested than the control (basic soap). Conclusion: The hexane extract of
Morinda morindoides leaves incorporated in soap exerted antifungal
activity against the fungal strains tested. Thus, this soap formulation
may find use in the treatment of dermatomycoses. |
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ISSN: | 1596-5996 1596-5996 1596-9827 |
DOI: | 10.4314/tjpr.v9i3.56283 |