The Epithelial-to-Mesenchymal Transition (EMT), a Particular Case

Constitutive heterochromatin, an essential structure that has been conserved throughout evolution, is required to maintain genome stability. Although heterochromatin is enriched for repressive traits, it can be actively transcribed to generate thousands of noncoding RNAs that are required for correc...

Full description

Saved in:
Bibliographic Details
Published in:Molecular & cellular oncology 2014-06, Vol.1 (2), p.e960770-e960770
Main Authors: Cebrià-Costa, Joan Pau, Millanes-Romero, Alba, de Herreros, Antonio García, Peiró, Sandra
Format: Article
Language:English
Subjects:
epithelial to mesenchymal transition
heterochromatin
histones
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Constitutive heterochromatin, an essential structure that has been conserved throughout evolution, is required to maintain genome stability. Although heterochromatin is enriched for repressive traits, it can be actively transcribed to generate thousands of noncoding RNAs that are required for correct chromatin assembly. Despite the importance of this structure, how and why heterochromatin transcription is regulated, and the proteins responsible for this regulation, remain poorly understood. Here, we summarize recent findings in heterochromatin transcription regulation during different cellular processes with a focus on the epithelial-mesenchymal transition (EMT), which elicits important changes in cell behavior, has a key role in early development, and is involved in cancer progression.
ISSN:2372-3556
2372-3548
2372-3556
DOI:10.4161/23723548.2014.960770