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Rise and fall of deleterious variants: the origins of modern genetic diseases
For two decades, sequencing genomes has significantly helped to identify genetic causes of diseases observed in modern humans, leading to the emergence of genetic medicine. This raises questions about the presence of deleterious variants, and consequently diseases, in ancient humans too, as well as...
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Published in: | Bulletins et Mémoires de la Société d’Anthropologie de Paris 2022-01, Vol.34 (S) |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | For two decades, sequencing genomes has significantly helped to identify genetic causes of diseases observed in modern humans, leading to the emergence of genetic medicine. This raises questions about the presence of deleterious variants, and consequently diseases, in ancient humans too, as well as when and where these variants first appeared during human evolution. As the Neolithic transition brought a major change in diet and life style in Western Eurasia, we examined the health status of p... |
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ISSN: | 0037-8984 1777-5469 |
DOI: | 10.4000/bmsap.8987 |