Green Tea, Black Tea, and Oolong Tea Polyphenols Reduce Visceral Fat and Inflammation in Mice Fed High-Fat, High-Sucrose Obesogenic Diets

Green tea (GT) and caffeine in combination were shown to increase energy expenditure and fat oxidation, but less is known about the effects of black tea (BT) and oolong tea (OT). This study investigated whether decaffeinated polyphenol extracts from GT, BT, and OT decrease body fat and inflammation...

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Published in:The Journal of nutrition 2014-09, Vol.144 (9), p.1385-1393
Main Authors: Heber, David, Zhang, Yanjun, Yang, Jieping, Ma, Janice E., Henning, Susanne M., Li, Zhaoping
Format: Article
Language:English
Subjects:
Adiponectin - metabolism
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Camellia sinensis - chemistry
Chemokine CCL2 - genetics
Chemokine CCL2 - metabolism
Diet - adverse effects
Dietary Fats - adverse effects
Dietary Sucrose - adverse effects
Eating - drug effects
Eye Proteins - metabolism
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Inflammation - blood
Inflammation - drug therapy
Inflammation - etiology
Intra-Abdominal Fat - metabolism
Male
Mice, Inbred C57BL
Neovascularization, Physiologic - drug effects
Nerve Growth Factors - metabolism
Obesity, Abdominal - blood
Obesity, Abdominal - etiology
Obesity, Abdominal - prevention & control
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polyphenols - pharmacology
Polyphenols - therapeutic use
Serpins - metabolism
Tea - chemistry
Vascular Endothelial Growth Factor A - metabolism
Vascular Endothelial Growth Factor Receptor-2 - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weight Loss - drug effects
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Summary:Green tea (GT) and caffeine in combination were shown to increase energy expenditure and fat oxidation, but less is known about the effects of black tea (BT) and oolong tea (OT). This study investigated whether decaffeinated polyphenol extracts from GT, BT, and OT decrease body fat and inflammation in male C57BL/6J mice fed high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose)] diets. Mice were fed either an HF/HS diet with 0.25% of polyphenol from GT, OT, or BT or a low-fat/high-sucrose [LF/HS (10.6% energy from fat, 25% energy from sucrose)] diet for 20 wk. Monomeric tea polyphenols were found in the liver and adipose tissue of mice fed the HF/HS diet with GT polyphenols (GTPs) and OT polyphenols (OTPs) but not BT polyphenols (BTPs). Treatment with GTPs, OTPs, BTPs, and an LF/HS diet led to significantly lower body weight, total visceral fat volume by MRI, and liver lipid weight compared with mice in the HF/HS control group. Only GTPs reduced food intake significantly by ∼10%. GTP, BTP, and LF/HS-diet treatments significantly reduced serum monocyte chemotactic protein-1 (MCP-1) compared with HF/HS controls. In mesenteric fat, monocyte chemotactic protein-1 (Mcp1) gene expression was significantly decreased by treatment with GTPs, BTPs, OTPs, and an LF/HS diet and in liver tissue by GTP and BTP treatments. Mcp1 gene expression in epididymal fat was significantly decreased by the BTP and LF/HS diet interventions. In epididymal fat, consistent with an anti-inflammatory effect, adiponectin gene expression was significantly increased by GTPs and OTPs. Angiogenesis during adipose tissue expansion is anti-inflammatory by maintaining adipocyte perfusion. We observed significantly increased gene expression of vascular endothelial growth factor A by GTPs and vascular endothelial growth factor receptor 2 by BTPs and the LF/HS diet and a decrease in pigment epithelium-derived factor gene expression by OTPs and BTPs. In summary, all 3 tea polyphenol extracts induced weight loss and anti-inflammatory and angiogenic effects, although the tissue content of polyphenols differed significantly.
ISSN:0022-3166
1541-6100
DOI:10.3945/jn.114.191007