Whole Grains Are Associated with Serum Concentrations of High Sensitivity C-Reactive Protein among Premenopausal Women

In premenopausal women, elevated C-reactive protein (CRP) concentrations have been associated with an increased risk of negative reproductive outcomes. Whole grain consumption has been associated with lower CRP concentrations in older women; however, less is known about this relationship in younger...

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Published in:The Journal of nutrition 2010-09, Vol.140 (9), p.1669-1676
Main Authors: Gaskins, Audrey J, Mumford, Sunni L, Rovner, Alisha J, Zhang, Cuilin, Chen, Liwei, Wactawski-Wende, Jean, Perkins, Neil J, Schisterman, Enrique F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
blood serum
C-reactive protein
C-Reactive Protein - metabolism
chemical concentration
Cohort Studies
Diet
diet recall
Diet Surveys
Edible Grain - chemistry
Feeding Behavior
Feeding. Feeding behavior
Female
Food Analysis
functional foods
Fundamental and applied biological sciences. Psychology
Humans
menopause
New York
premenopausal women
Premenopause
risk factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
whole grain foods
women
Young Adult
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Summary:In premenopausal women, elevated C-reactive protein (CRP) concentrations have been associated with an increased risk of negative reproductive outcomes. Whole grain consumption has been associated with lower CRP concentrations in older women; however, less is known about this relationship in younger women. We investigated whether whole grain intake was associated with serum high sensitivity CRP (hs-CRP) concentrations in young women. BioCycle was a prospective cohort study conducted at the University of Buffalo from 2005 to 2007, which followed 259 healthy women aged 18-44 y for le 2 menstrual cycles. hs-CRP concentrations were measured longitudinally le 8 times/cycle with visits standardized to menstrual cycle phase. Whole grain intake was estimated by 24-h recalls le 4 times/cycle. Servings were defined as 16 g or 125 mL of a 100% whole grain food. Whole grain intake was inversely associated with hs-CRP concentrations after adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP concentrations (P = 0.02) and consumers of ge 1 serving/d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers. Women who consumed ge 1 serving/d of whole grain had a lower probability of having moderate (P = 0.008) or elevated (P = 0.001) hs-CRP according to the AHA criteria compared with nonconsumers. Given that elevated concentrations of hs-CRP have been linked to adverse reproductive outcomes and pregnancy complications, interventions targeting whole grain consumption may have the potential to improve health status among young women.
ISSN:0022-3166
1541-6100
DOI:10.3945/jn.110.124164