Human papillomavirus infection and expression of ATPase family AAA domain containing 3A, a novel anti-autophagy factor, in uterine cervical cancer

Our aim was to determine the association of human papillomavirus (HPV) infection with the expression of ATPase family AAA domain containing 3A (ATAD3A), an anti-autophagy factor, in uterine cervical cancer (UCC). The HPV genotype was determined by an Easychip HPV blot assay. ATAD3A expression was de...

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Bibliographic Details
Published in:International journal of molecular medicine 2011-11, Vol.28 (5), p.689-696
Main Authors: Chen, Tai-Chang, Hung, Yao-Ching, Lin, Tze-Yi, Chang, Hui-Wen, Chiang, I-Ping, Chen, Yueh-Ying, Chow, Kuan-Chih
Format: Article
Language:English
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Summary:Our aim was to determine the association of human papillomavirus (HPV) infection with the expression of ATPase family AAA domain containing 3A (ATAD3A), an anti-autophagy factor, in uterine cervical cancer (UCC). The HPV genotype was determined by an Easychip HPV blot assay. ATAD3A expression was determined by immunohistochemical staining. High-risk HPV (hrHPV) was detected in 184 (88.9%) of 207 UCC cases. ATAD3A expression was detected in 164 (79.2%) UCC cases. A significant correlation was found between ATAD3A expression and the presence of hrHPV (p
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2011.743