Predictors of Survival Outcomes in Non-Metastatic Renal Cell Carcinoma in Latin America and Spain: A Multicentric Analysis

Background: Renal cell carcinoma (RCC) is a lethal neoplasia. Data from Latin America are scarce, and the distinct ethnic origins of this population could affect predictive or prognostic factors. Objective: We aim to describe a large cohort of non-metastatic renal cell carcinoma, identifying the dem...

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Published in:Kidney cancer 2019-01, Vol.3 (4), p.253-261
Main Authors: Zequi, Stênio de Cássio, Mourão, Thiago Camelo, de Oliveira, Max Moura, Curado, Maria Paula, Gueglio, Guilhermo, da Costa, Walter Henriques, Zuñiga, Alvaro, Bengió, Rubén, Scorticati, Carlos, Rodriguez, Francisco, Autran, Ana Maria, Martínez, Pablo, Ameri, Carlos, Mingote, Pablo, Secin, Fernando Pablo, Decia, Ricardo, da Cunha, Isabela Werneck, Guimarães, Gustavo Cardoso, Glina, Sidney, Palou, Joan, Abreu, Diego
Format: Article
Language:English
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Summary:Background: Renal cell carcinoma (RCC) is a lethal neoplasia. Data from Latin America are scarce, and the distinct ethnic origins of this population could affect predictive or prognostic factors. Objective: We aim to describe a large cohort of non-metastatic renal cell carcinoma, identifying the demographic, clinical, and pathological prognostic factors for survival. Methods: We used a multi-institutional retrospective cohort involving 5,670 patients who underwent radical or partial nephrectomy across seven Latin American countries and Spain from 1980 to 2016. The variables were compared, and Kaplan–Meier curves were used to estimate the overall survival (OS) and cancer-specific survival (CSS). Results: The clear cell subtype represented 66.7% of RCC, followed by chromophobe (13.7%), papillary (5.2%), and others (14.4%). Furthermore, 72.3% of renal masses were 7 cm (HR: 1.64). Conclusions: Our findings agreed with those reported for some developed countries. We emphasize that ASA and peri-renal fat invasion as prognostic factors deserve further study. Information regarding microvascular invasion should be regularly incorporated in pathological reports.
ISSN:2468-4562
2468-4570
DOI:10.3233/KCA-190068