Alpha-Tocopherol and Fatty Acid Levels in Red Blood Cells in Patients Treated with Antiepileptic Drugs

Red blood cell (RBC) alpha-tocopherol and fatty acid levels in children undergoing long-term antiepileptic therapy were examined. Antiepileptic drugs included diphenylhydantoin (PHT), valproic acid (VPA), phenobarbital (PB), and carbamazepine (CBZ). RBC alpha-tocopherol levels were low in patients r...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 1988, Vol.34(6), pp.627-631
Main Authors: TAMAI, Hiroshi, WAKAMIYA, Eiji, MINO, Makoto, IWAKOSHI, Mie
Format: Article
Language:English
Subjects:
Adolescent
alpha-tocopherol
Anticonvulsants - adverse effects
antiepileptic drug
Child
Child, Preschool
children
Chromatography, Gas
epi-lepsy
Erythrocytes - analysis
Erythrocytes - drug effects
fatty acid
Fatty Acids - blood
Humans
plasma
red blood cell
vitamin E
Vitamin E - blood
Vitamin E - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Red blood cell (RBC) alpha-tocopherol and fatty acid levels in children undergoing long-term antiepileptic therapy were examined. Antiepileptic drugs included diphenylhydantoin (PHT), valproic acid (VPA), phenobarbital (PB), and carbamazepine (CBZ). RBC alpha-tocopherol levels were low in patients receiving multi-drug combination therapy, as compared with children receiving no treatment (controls), but plasma alpha-tocopherol levels were the same in both groups. With respect to fatty acid composition in RBCs, docosahexaenoic acid (DHA) level was decreased in children receiving antiepileptic therapy, while no changes were documented in the other fatty acids.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.34.627