THE RELATIONSHIP OF POST-OP TRAMADOL ACTIVITY TO THE CYP2D617 GENOME IN PATIENTS WHICH WAS APPLIED TOTAL KNEE ARTROPLASTY

Objective: In our study where we examined the effect of tramadol maintenance on VAS score in geriatric patients, we observed until the post-op 60th minute. Investigation of the incidence of pain in patients who underwent knee arthroplasty in the study. We aimed to examine the effect of the *17 allel...

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Published in:Pamukkale Medical Journal 2023-12
Main Authors: ÖK, Nusret, GÜRBÜZ, Muhammet Erdi, KOSELER, Aylin
Format: Article
Language:English
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Summary:Objective: In our study where we examined the effect of tramadol maintenance on VAS score in geriatric patients, we observed until the post-op 60th minute. Investigation of the incidence of pain in patients who underwent knee arthroplasty in the study. We aimed to examine the effect of the *17 allele of the CYP2D6 genome on the post-op tramadol activity. Methods: 110 patients who underwent total knee arthroplasty in our service in Pamukkale University Faculty of Medicine, Department of Orthopedics and Traumatology, and 100 healthy individuals without complaints as the control group were included in this study. Tramadol 100 mg (contramal) was administered intravenously to each patient. The port-op 0-15-30-45-60.min VAS scores of the patients were recorded. Results: The mean age of the patients was 62.36 years. While 86.4% of the patients in our study were female, this rate was 46% in the control group. We found 3.65% (n=14) *17 carriers with the presence of *17 allele in the patient (n=7) and control groups (n=7). The VAS score of the patients in the *1/*1 group at VAS post-op 0th minute was 91.07. The VAS score of the patients in the *1/*17 group was 95.0. There was no statistically significant difference between genomes (p>0.050). Similarly post-op 15., 30., 45. And 60. Min There was no statistically significant difference between the genomes per (p>0.050). We observed a statistically significant decrease in the postoperative VAS score between 0-60 minutes in both groups in time-dependent variation (p=0.000). Conclusion: When we examine the studies with different results in the literature in which tramadol is classified as IM or EM in relation to the *17 allele, according to the results of our study: We think that the *17 allele should be evaluated as EM and NM. Amaç: Geriatrik hastalarda tramadol idamesinin VAS skoruna etkisini incelediğimiz çalışmamızda post-op 60. dakikaya kadar gözlem yaptık. Çalışmada Diz artroplastisi uygulanan hastalarda ağrı insidansının incelenmesi Post-op tramadol etkinliğine CYP2D6 genomunun *17 alelinin etkisini incelemeyi amaçladık. Yöntem: Bu çalışmaya Pamukkale Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı’nda servisimize total diz antroplastisi uygulanan 110 hasta ve kontrol grubu olarak şikâyeti olmayan sağlıklı 100 kişi dahil edildi. Her hastaya intravenöz yoldan 100 mg Tramadol (contramal) uygulandı. Hastaların port-op 0-15-30-45-60.dk VAS skorları kaydedildi. Bulgular: Hastalar ortalama 62,36 yaşınd
ISSN:1309-9833
DOI:10.31362/patd.1351539