Cancer-free survival of psoriasis patients treated with methotrexate and cyclosporine combination

Abstract Context: Combination of methotrexate and cyclosporine was used and reported to be effective for recalcitrant psoriasis patients. Also each agent is accused for development of malignancies. Objective: To evaluate the cancer-free survival of psoriasis patients who received methotrexate and cy...

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Bibliographic Details
Published in:Cutaneous and ocular toxicology 2014-09, Vol.33 (3), p.181-183
Main Authors: Aydin, Fatma, Yuksel, Esra Pancar, Senturk, Nilgun, Canturk, Tayyar, Turanli, Ahmet Yasar
Format: Article
Language:English
Subjects:
Adult
Cyclosporine
Cyclosporine - therapeutic use
Dermatologic Agents - therapeutic use
Drug Therapy, Combination
Female
Humans
Immunosuppressive Agents - therapeutic use
Male
malignancy
methotrexate
Methotrexate - therapeutic use
Middle Aged
Neoplasms - epidemiology
psoriasis
Psoriasis - drug therapy
Psoriasis - epidemiology
Surveys and Questionnaires
Turkey - epidemiology
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Summary:Abstract Context: Combination of methotrexate and cyclosporine was used and reported to be effective for recalcitrant psoriasis patients. Also each agent is accused for development of malignancies. Objective: To evaluate the cancer-free survival of psoriasis patients who received methotrexate and cyclosporine treatment at the same time. Methods: Psoriasis patients who had been treated with combination of cyclosporine and methotrexate between March 2000 and April 2005 were questioned in 2011. A diagnosis of new cancer during follow-up period was asked and also each patient was evaluated by a questionnaire. Results: Seventeen psoriasis patients were not treated due to a diagnosis of new cancer during the follow-up period. Also none of them complained of possible symptoms of skin or lymphoproliferative malignancies. The median follow-up time was 76 months. Conclusion: Psoriasis patients who had been treated with methotrexate and cyclosporine combination did not report a detected malignant disease.
ISSN:1556-9527
1556-9535
DOI:10.3109/15569527.2013.825805