Carbetocin versus oxytocin for prevention of postpartum hemorrhage in obese nulliparous women undergoing emergency cesarean delivery

Objective: To assess and compare the effectiveness and safety of single IV polus dose of carbetocin, versus IV oxytocin infusion in the prevention of PPH in obese nulliparous women undergoing emergency Cesarean Delivery. Methods: A double-blinded randomized-controlled trial was conducted on 180 preg...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2016-04, Vol.29 (8), p.1257-1260
Main Authors: El Behery, Manal M., El Sayed, Gamal Abbas, El Hameed, Azza A. Abd, Soliman, Badeea S., Abdelsalam, Walid A., Bahaa, Abeer
Format: Article
Language:English
Subjects:
Adult
Carbitocin
Cesarean Section
Double-Blind Method
Emergencies
emergency C.S
Female
Hemoglobins - analysis
Humans
obesity
Obesity - complications
Oxytocics - therapeutic use
oxytocin
Oxytocin - analogs & derivatives
Oxytocin - therapeutic use
Parity
postpartum hemorrhage
Postpartum Hemorrhage - prevention & control
Pregnancy
Uterine Contraction - drug effects
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Summary:Objective: To assess and compare the effectiveness and safety of single IV polus dose of carbetocin, versus IV oxytocin infusion in the prevention of PPH in obese nulliparous women undergoing emergency Cesarean Delivery. Methods: A double-blinded randomized-controlled trial was conducted on 180 pregnant women with BMI >30. Women were randomized to receive either oxytocin or carbetocin during C.S. The primary outcome measure was major primary PPH >1000 ml within 24 h of delivery as per the definition of PPH by the World Health Organization Secondary outcome measures were hemoglobin and hematocrit changes pre- and post-delivery, use of further ecobolics, uterine tone 2 and 12-h postpartum and adverse effects. Results: A significant difference in the amount of estimated blood loss or the incidence of primary postpartum haemorrhage (>1000 ml) in both groups. Haemoglobin levels before and 24-h postpartum was similar. None from the carbetocin group versus 71.5% in oxytocin group needed additional utrotonics (p 
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2015.1043882