Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy

Context: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes. Objective: We aimed to determine miRNA expression levels in plasma of children with DCM. Materials and methods: Plasma e...

Full description

Saved in:
Bibliographic Details
Published in:Biomarkers 2016-01, Vol.21 (1), p.56-61
Main Authors: Enes Coşkun, Mehmet, Kervancıoğlu, Mehmet, Öztuzcu, Serdar, Yılmaz Coşkun, Fatma, Ergün, Sercan, Başpınar, Osman, Kılınç, Metin, Temel, Levent, Coşkun, Mehmet Yavuz
Format: Article
Language:English
Subjects:
Adolescent
Biomarkers - blood
Cardiomyopathy, Dilated - blood
Cardiomyopathy, Dilated - diagnostic imaging
Case-Control Studies
Child
Child, Preschool
Children
dilated cardiomyopathy
Gene Expression Profiling
Humans
Infant
microRNA
MicroRNAs - blood
Transcriptome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Context: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes. Objective: We aimed to determine miRNA expression levels in plasma of children with DCM. Materials and methods: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children. Results: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients. Discussion: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.
ISSN:1354-750X
1366-5804
DOI:10.3109/1354750X.2015.1118533