Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL...

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Bibliographic Details
Published in:Pharmacogenomics 2020-06, Vol.21 (8), p.533-540
Main Authors: Pisanu, Claudia, Congiu, Donatella, Manchia, Mirko, Caria, Paola, Cocco, Cristina, Dettori, Tinuccia, Frau, Daniela Virginia, Manca, Elias, Meloni, Anna, Nieddu, Mariella, Noli, Barbara, Pinna, Federica, Robledo, Renato, Sogos, Valeria, Ferri, Gian Luca, Carpiniello, Bernardo, Vanni, Roberta, Bocchetta, Alberto, Severino, Giovanni, Ardau, Raffaella, Chillotti, Caterina, Zompo, Maria Del, Squassina, Alessio
Format: Article
Language:English
Subjects:
Adult
aging
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Bipolar Disorder - diagnosis
Bipolar Disorder - drug therapy
Bipolar Disorder - genetics
Female
Genome-Wide Association Study - methods
Humans
Leukocytes - drug effects
Leukocytes - physiology
Lithium Compounds - pharmacology
Lithium Compounds - therapeutic use
Longitudinal Studies
Male
mendelian randomization mood disorders
Middle Aged
mood stabilizers
pharmacogenetics
Telomere - drug effects
Telomere - physiology
telomere shortening
Telomere Shortening - drug effects
Telomere Shortening - physiology
telomeres
Treatment Outcome
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Summary:To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2020-0028