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ANTI-INFLAMMATORY EFFECT OF ZANTHOXYLUM BUNGEANUM-CAKE-SEPARATED MOXIBUSTION ON RHEUMATOID ARTHRITIS RATS
Background: Zanthoxylum bungeanum-cake-separated moxibustion (ZBCS-moxi), a kind of traditional therapy of moxibustion, has been used in China since 340 B.C. However, its mechanism remains unclear. So, this study was attempted to reveal the anti-inflammatory effect of ZBCS-moxi on rheumatoid arthrit...
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Published in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2015-12, Vol.13 (1), p.45-52 |
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Main Authors: | , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Background: Zanthoxylum bungeanum-cake-separated moxibustion (ZBCS-moxi), a kind of traditional therapy of moxibustion, has been used
in China since 340 B.C. However, its mechanism remains unclear. So, this study was attempted to reveal the anti-inflammatory effect of
ZBCS-moxi on rheumatoid arthritis (RA) rats.
Methods and Materials: Forty health SD female rats were randomly divided into 4 groups (n=10/group): control group, model group,
Zanthoxylum bungeanum-cake-separated moxibustion group (ZBCS-moxi group) and Aconitum carmichaeli-cake-separated moxibustion group
(ACCS-moxi group). RA model was induced by injecting 0.1 ml Freund’s complete adjuvant (FCA) into the right hind paw of rats. Eleven days
after CFA injection, the rats in ZBCS-moxi group received Zanthoxylum bungeanum- cake-separated moxibustion on Shenshu (BL23), Zusanli
(ST36) acupoints and the dorsum right hind paw respectively for 3 weeks. The ACCS-moxi group was used as a positive control, while the rats
were treated with Aconitum carmichaeli-cake-separated moxibustion on the same acupoints and courses. After a 3-week treatment, we
investigated anti-inflammatory effect by measuring the paw volume, observing the pathologic morphology of synovial membranes and detecting
the concentration of IL-1β and TNF-α in serum.
Results: Compared to model group, the swollen paw volumes, the synovial hyperplasia and pannus formation of synovial membranes and the
concentration of IL-1β and TNF-α in serum decreased obviously (P |
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ISSN: | 0189-6016 2505-0044 |
DOI: | 10.21010/ajtcam.v13i1.7 |