Synthesis and characterization of the graft copolymer PTFE-g-HEMA using gamma rays for the load and delivery of ciprofloxacin

The aim of this study was to develop a drug delivery copolymer. Hydroxyethyl methacrylate (HEMA) was grafted onto poly(tetrafluoroethylene) films using gamma rays as the initiator agent. The optimal conditions for the grafting procedure were determined through a series of experiments, considering th...

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Bibliographic Details
Published in:	MRS communications 2024-02, Vol.14 (1), p.26-33
Main Authors:	Ramírez-Flores, Benito E., Bucio, Emilio
Format:	Article
Language:	eng
Subjects:	Biomaterials Characterization and Evaluation of Materials Chemistry and Materials Science Materials Engineering Materials Science Nanotechnology Polymer Sciences Research Letter
Online Access:	Get full text
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Summary:	The aim of this study was to develop a drug delivery copolymer. Hydroxyethyl methacrylate (HEMA) was grafted onto poly(tetrafluoroethylene) films using gamma rays as the initiator agent. The optimal conditions for the grafting procedure were determined through a series of experiments, considering the following factors: reaction time, temperature, HEMA concentration, solvent type, and gamma-ray doses. Grafting was accomplished using the oxidative-pre-irradiation method. The resulting copolymer was subjected to various characterizations, including thermal analysis (TGA and DSC), FTIR-ATR spectroscopy, contact angle measurements, and assessment of physicochemical properties. Additionally, its ability to load and release ciprofloxacin was evaluated. Graphical abstract
ISSN:	2159-6867 2159-6867