Effects of Dai-kenchu-to on Intestinal Obstruction Following Laparotomy

To confirm the usefulness of Dai-kenchu-to for intestinal obstruction, investigation of the effects of Dai-kenchu-to on postoperative intestinal adhesion was conducted. Repeated administrations of Dai-kenchu-to (100 or 300 mg/kg) significantly inhibited the formation of intestinal obstruction. Motor...

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Bibliographic Details
Published in:Journal of Smooth Muscle Research 1999, Vol.35(2), pp.47-54
Main Authors: HAYAKAWA, Terumasa, KASE, Yoshio, SAITO, Kazuko, HASHIMOTO, Kazunori, ISHIGE, Atsushi, KOMATSU, Yasuhiro, SASAK, Hiroshi
Format: Article
Language:English
Subjects:
Animals
COX activity
Dai-kenchu-to
Disease Models, Animal
Drugs, Chinese Herbal - pharmacology
Ileum - drug effects
ileus
intestinal adhesion
Intestinal Obstruction - etiology
Intestinal Obstruction - prevention & control
Male
Mice
Mice, Inbred ICR
Pharmaceutical Preparations
Plant Extracts - pharmacology
Postoperative Complications - prevention & control
Prostaglandin-Endoperoxide Synthases - drug effects
Rats
Rats, Sprague-Dawley
Talc - adverse effects
Tissue Adhesions - etiology
Tissue Adhesions - prevention & control
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Summary:To confirm the usefulness of Dai-kenchu-to for intestinal obstruction, investigation of the effects of Dai-kenchu-to on postoperative intestinal adhesion was conducted. Repeated administrations of Dai-kenchu-to (100 or 300 mg/kg) significantly inhibited the formation of intestinal obstruction. Motor disturbance and inflammation are thought to be involved in the etiology of intestinal adhesion. A single treatment of Dai-kenchu-to (300mg/kg) significantly reduce intestinal transit time in postoperative ileus and chemically-induced ileus. Dai-kenchu-to (10-4 g/ml) significantly inhibited COX-2 activity. These results suggest that Dai-kenchu-to prevents postoperative intestinal adhesion by gastroprokinetic and anti-inflammatic effects. Dai-kenchu-to thus demonstrates positive effect on postoperative ileus.
ISSN:0916-8737
1884-8796
DOI:10.1540/jsmr.35.47