Faecal biomarkers of neutrophil and eosinophil origin reflect the response to biological therapy and corticosteroids in patients with IBD

Faecal calprotectin (FC) is a non-invasive tool for examining response to biologics in inflammatory bowel disease (IBD), but its performance in relation to other novel faecal markers of various cellular origins is unknown. We performed a prospective multicentre cohort study and included patients wit...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and translational gastroenterology 2023-06
Main Authors: Lundström, Maria Ling, Peterson, Christer, Lampinen, Maria, Hedin, Charlotte R H, Keita, Åsa V, Kruse, Robert, Magnusson, Maria K, Lindqvist, Carl Mårten, Repsilber, Dirk, D'Amato, Mauro, Hjortswang, Henrik, Strid, Hans, Rönnblom, Anders, Söderholm, Johan D, Öhman, Lena, Venge, Per, Halfvarson, Jonas, Carlson, Marie
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Faecal calprotectin (FC) is a non-invasive tool for examining response to biologics in inflammatory bowel disease (IBD), but its performance in relation to other novel faecal markers of various cellular origins is unknown. We performed a prospective multicentre cohort study and included patients with active IBD who provided a faecal sample at initiation of biological therapy. Levels of FC, myeloperoxidase (MPO), human neutrophil lipocalin (HNL), and eosinophil-derived neurotoxin (EDN) were analysed and related to clinical remission status at 3 months. Changes in levels of markers at 3 months were calculated and the impact of concomitant use of corticosteroids at baseline was estimated. In patients achieving clinical remission (n=27), a decrease in levels of FC (p=0.005), MPO (p
ISSN:2155-384X
2155-384X
DOI:10.14309/ctg.0000000000000605