Effects of dried bonito (Katsuobushi) and captopril, an angiotensin I-converting enzyme inhibitor, on rat isolated aorta: A possible mechanism of antihypertensive action

In order to elucidate the mechanism of the antihy-pertensive action of dried bonito (katsuobushi), we compared the effects of dried bonito extracts with those of captopril, an Angiotensin I-Converting Enzyme (ACE) inhibitor, on aorta preparations isolated from rats. Dried bonito extracts (3 x 10E-4...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-01, Vol.69 (5), p.911-915
Main Authors: Kouno, K. (Ochanomizu Univ., Tokyo (Japan)), Hirano, S, Kuboki, H, Kasai, M, Hatae, K
Format: Article
Language:English
Subjects:
ANGIOTENSIN
Angiotensin-Converting Enzyme Inhibitors - pharmacology
angiotensin-I converting enzyme inhibitor
Animals
Antihypertensive Agents - pharmacology
antihypertensive effect
Aorta - drug effects
ARTERIES
Biological and medical sciences
BLOOD PRESSURE
BONITOS
captopril
Captopril - pharmacology
dried bonito (katsuobushi)
DRUGS
ENZYME INHIBITORS
EXTRACTS
Fish Products
Fundamental and applied biological sciences. Psychology
HYPERTENSION
In Vitro Techniques
Norepinephrine - pharmacology
Potassium Chloride - pharmacology
rat aorta
RATS
Vasoconstriction - drug effects
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Summary:In order to elucidate the mechanism of the antihy-pertensive action of dried bonito (katsuobushi), we compared the effects of dried bonito extracts with those of captopril, an Angiotensin I-Converting Enzyme (ACE) inhibitor, on aorta preparations isolated from rats. Dried bonito extracts (3 x 10E-4 to 3 x 10E-3 g/ml) more potently relaxed contractions induced by norepineph-rine (10E-7 M) than contractions induced by KCl (55.9 mM). Dried bonito extracts (3 x 10E-3 g/ml) slightly inhibited 10E-7M angiotensin I-induced contractions. In contrast, captopril (10E-8 to 10E-7 M) did not affect 10E-7 M norepinephrine- or 55.9 mM KCl-induced contractions, but a higher concentration of captopril (10E-6 M) very slightly relaxed it. Captopril (10E-8 to 10E-6 M) markedly inhibited 10E-7 M angiotensin I-induced contractions in a concentration-dependent manner. These results suggest that antihypertensive mechanism of action induced by dried bonito involves direct action on vascular smooth muscle in addition to ACE-inhibitory activity.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.69.911