Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma

Background The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins (RLPs) and high-density lipoprotein (HDL) in human plasma. Metho...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2010-09, Vol.47 (5), p.423-431
Main Authors: Nakajima, K, Kobayashi, J, Mabuchi, H, Nakano, T, Tokita, Y, Nagamine, T, Imamura, S, Ai, M, Otokozawa, S, Schaefer, E F
Format: Article
Language:English
Subjects:
Angiopoietin-like Proteins
Angiopoietins - blood
Fasting - blood
Humans
Lipase - blood
Lipoprotein Lipase - blood
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Liver - enzymology
Male
Middle Aged
Postprandial Period
Triglycerides - blood
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Summary:Background The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins (RLPs) and high-density lipoprotein (HDL) in human plasma. Methods ANGPTL3, LPL activity, HTGL activity, RLP-C and RLP-TG and small, dense LDL-cholesterol (sd LDL-C) were measured in 20 overweight and obese subjects in the fasting and postprandial states. Results Plasma TG, RLP-C, RLP-TG and sd LDL-C were inversely correlated with LPL activity both in the fasting and postprandial states, but not correlated with HTGL activity and ANGPTL3. However, plasma HDL-C was positively correlated with LPL activity both in the fasting and postprandial states, while inversely correlated with HTGL activity. ANGPTL3 was inversely correlated with HTGL activity both in the fasting and postprandial states, but not correlated with LPL activity. Conclusion HTGL plays a major role in HDL metabolism, but not RLP metabolism. These findings suggest that ANGPTL3 is strongly associated with the inhibition of HTGL activity and regulates HDL metabolism, but not associated with the inhibition of LPL activity for the metabolism of RLPs in human plasma.
ISSN:0004-5632
1758-1001
DOI:10.1258/acb.2010.009307