Antenatal oral glucose-tolerance test values and pregnancy outcomes

Objective The aim of the present study was to explore the impact of individual blood glucose values (n = 4; i.e. fasting and 1, 2 and 3 h following oral glucose administration) obtained during antenatal oral glucose‐tolerance testing, together with two different sets of criteria used for diagnosis o...

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Bibliographic Details
Published in:	The International journal of pharmacy practice 2008-06, Vol.16 (3), p.189-197
Main Authors:	Elnour, Asim Ahmed, McElnay, James C.
Format:	Article
Language:	eng
Online Access:	Get full text
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Summary:	Objective The aim of the present study was to explore the impact of individual blood glucose values (n = 4; i.e. fasting and 1, 2 and 3 h following oral glucose administration) obtained during antenatal oral glucose‐tolerance testing, together with two different sets of criteria used for diagnosis of gestational diabetes mellitus (GDM) — Carpenter and Coustan Criteria (CCC) and National Diabetes Data Group (NDDG) criteria — in predicting pregnancy outcomes and maternal insulin need. Setting Al Ain Hospital, United Arab Emirates. Results The maternal and neonatal outcomes indicated that the number of abnormally elevated antenatal OGTT values obtained during the diagnosis of GDM was significantly correlated with development of a number of pregnancy complications. Data analysis also indicated that the number of abnormal diagnostic antenatal OGTT values using CCC was significantly correlated with development of postpartum diabetes mellitus (P = 0.044) within 6months of delivery. The number of abnormal OGTT values significantly contributed to insulin need during the index pregnancy (P < 0.05). The CCC approach was more sensitive than the NDDG methodology for predicting the onset of GDM and a number of the associated complications. Conclusions The study highlighted the importance of abnormal values for antenatal OGTT in identifying the need for insulin management in women with GDM.
ISSN:	0961-7671 2042-7174