PSUN55 Abnormal Body Fat Distribution in Lean Individuals with Metabolic Abnormalities

Abstract Background Truncal obesity has long been considered an essential driver of metabolic abnormalities, but it is common for lean individuals with body mass index (BMI) 130/85 mmHg, triglyceride >150 mg/dL, HDL 5.7) were considered MUL, while those with 1 component or less were considered MH...

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Published in:Journal of the Endocrine Society 2022-11, Vol.6 (Supplement_1), p.A255-A256
Main Authors: Badour, Sanaa, Valderrãbano, Rodrigo, Ferri-Guerra, Juliana, Barb, Diana, Garg, Rajesh
Format: Article
Language:English
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Summary:Abstract Background Truncal obesity has long been considered an essential driver of metabolic abnormalities, but it is common for lean individuals with body mass index (BMI) 130/85 mmHg, triglyceride >150 mg/dL, HDL 5.7) were considered MUL, while those with 1 component or less were considered MHL. Waist circumference was not considered in this study. Adults with a BMI less than 25 kg/m2 were included in the analysis. Unadjusted and adjusted binary logistic regression were used to analyze the association between metabolic abnormalities and various anthropometric indexes. Results The study population consisted of 119 lean adults with a mean age of 62±14 years and a mean BMI of 22±1.9 kg/m2. Majority of participants were white (88%, n=105) and included postmenopausal women (85%, n=101). A large proportion were of Hispanic ethnicity (41%, n=70). There were 69 (58%) MHL and 50 (42%) MUL individuals. MUL and MHL groups had comparable percentage of total body fat (34±6.6 versus 34±5.6, p=0.360), fat mass index (8.2±1.6 versus 8.1±1.5, p=0.360) and appendicular lean mass (kg/m2) (5.9±0.8 versus 5.8±0.7, p=0.420). However, compared to MHL, MUL subjects had significantly higher visceral adipose tissue (cm2) (87±40 versus 9±29, p=0.004), trunk-to-leg fat ratio (0.89±0.18 versus 0.77±0.13, p
ISSN:2472-1972
2472-1972
DOI:10.1210/jendso/bvac150.525