Endoplasmic Reticulum Stress

:  Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress‐sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human...

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Published in:Annals of the New York Academy of Sciences 2007-10, Vol.1113 (1), p.58-71
Main Authors: BÁNHEGYI, GÁBOR, BAUMEISTER, PETER, BENEDETTI, ANGELO, DONG, DEZHENG, FU, YONG, LEE, AMY S., LI, JIANZE, MAO, CHANGHUI, MARGITTAI, ÉVA, NI, MIN, PASCHEN, WULF, PICCIRELLA, SIMONA, SENESI, SILVIA, SITIA, ROBERTO, WANG, MIAO, YANG, WEI
Format: Article
Language:English
Subjects:
Animals
cerebral ischemia
endoplasmic reticulum
Endoplasmic Reticulum - physiology
glucocorticoids
GRP78
Heat-Shock Proteins - biosynthesis
Heat-Shock Proteins - genetics
Heat-Shock Proteins - physiology
Heat-Shock Response - physiology
Humans
metabolic syndrome
Molecular Chaperones - biosynthesis
Molecular Chaperones - genetics
Molecular Chaperones - physiology
obesity
plasma cell
stress
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Summary::  Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress‐sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1391.007