Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: a tool for comparing the efficacy of different treatment strategies and predicting outcome

Multiparametric immunophenotyping can be a sensitive method for analyzing the plasma cell (PC) compartment in patients with multiple myeloma because it discriminates between myelomatous and normal PCs. Using this approach, we compared the efficacy of high-dose chemotherapy followed by autologous ste...

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Bibliographic Details
Published in:	Blood 2002-03, Vol.99 (5), p.1853-1856
Main Authors:	San Miguel, Jesús F., Almeida, Julia, Mateo, Gema, Bladé, Joan, López-Berges, Consuelo, Caballero, Dolores, Hernández, José, Moro, Marı́a Jesús, Fernández-Calvo, Javier, Dı́az-Mediavilla, Joaquı́n, Palomera, Luis, Orfao, Alberto
Format:	Article
Language:	eng
Subjects:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antineoplastic Agents - administration & dosage Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Cell Count Disease-Free Survival Female Hematopoietic Stem Cell Transplantation Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Immunophenotyping Male Medical sciences Middle Aged Multiple Myeloma - blood Multiple Myeloma - diagnosis Multiple Myeloma - pathology Neoplasm, Residual - pathology Plasma Cells - immunology Plasma Cells - pathology Prognosis Therapeutic Equivalency Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Autologous
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Summary:	Multiparametric immunophenotyping can be a sensitive method for analyzing the plasma cell (PC) compartment in patients with multiple myeloma because it discriminates between myelomatous and normal PCs. Using this approach, we compared the efficacy of high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) with that of conventional chemotherapy. We found that ASCT provided a significantly greater reduction in the level of residual tumor PCs and with better recovery of normal PCs. This profile of coexistence of normal PCs and myelomatous PCs resembled that observed in monoclonal gammopathy of undetermined significance. We also found that treatment-induced changes in the PC compartment correlated with disease outcome. Thus, patients in whom at least 30% of gated PCs had a normal phenotype after treatment had a significantly longer progression-free survival (60 ± 6 months versus 34 ± 12 months;P = .02).
ISSN:	0006-4971 1528-0020