Development of a Novel L-Asparaginase with Enhanced Properties Using Ancestral Sequence Reconstruction

The overall survival of children with acute lymphoblastic leukemia (ALL) now exceeds 90% due to the precise disease risk stratification and intensification of multi-agent chemotherapy regimens. L-asparaginase (L-ASNase) is an indispensable biotherapeutic enzyme used in treatment of pediatric ALL. Di...

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Bibliographic Details
Published in:Blood 2023-11, Vol.142 (Supplement 1), p.4191-4191
Main Authors: Knight, Kristopher A, Brown, Harrison C., White, Kinnede R., Spencer, H. Trent, Doering, Christopher B, Raikar, Sunil S.
Format: Article
Language:English
Online Access:Get full text
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Summary:The overall survival of children with acute lymphoblastic leukemia (ALL) now exceeds 90% due to the precise disease risk stratification and intensification of multi-agent chemotherapy regimens. L-asparaginase (L-ASNase) is an indispensable biotherapeutic enzyme used in treatment of pediatric ALL. Discontinuation of L-ASNase treatment due to immunological or adverse reactions leads to significantly inferior disease-free survival (73% ±7% vs 92% ± 2%; P
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2023-190281