Amino Acid Stress Response Genes Promote L-Asparaginase Resistance in Pediatric Acute Lymphoblastic Leukemia

Amino Acid Stress Response Genes Promote L-Asparaginase Resistance in Pediatric Acute Lymphoblastic Leukemia

▪ Understanding the genomic and epigenetic mechanisms of drug resistance in pediatric acute lymphoblastic leukemia (ALL) is critical for further improvements in treatment outcome. The role of transcriptomic response in conferring resistance to l-asparaginase (LASP) is poorly understood, beyond aspar...

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Published in:Blood 2021-11, Vol.138 (Supplement 1), p.3304-3304
Main Authors: Ferguson, Daniel, McCorkle, J. Robert, Dong, Qian, Bonten, Erik, Yang, Wenjian, Bergeron, Brennan P., Autry, Robert J, Diedrich, Jonathan, Gocho, Yoshihiro, Bajpai, Richa, Crews, Kristine R., Pruett-Miller, Shondra M., Roberts, Kathryn G, Stock, Wendy, Mullighan, Charles G., Inaba, Hiroto, Jeha, Sima, Pui, Ching-Hon, Yang, Jun J., Relling, Mary V., Evans, William E., Savic, Daniel
Format: Article
Language:eng
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Summary:▪ Understanding the genomic and epigenetic mechanisms of drug resistance in pediatric acute lymphoblastic leukemia (ALL) is critical for further improvements in treatment outcome. The role of transcriptomic response in conferring resistance to l-asparaginase (LASP) is poorly understood, beyond asparagine synthetase (ASNS). We defined reproducible LASP response genes in LASP resistant and sensitive ALL cell lines (n = 7) as well as primary leukemia samples from newly diagnosed patients. We identified 2219 response genes (absolute log 2FC > 1.5, FDR p-value
ISSN:0006-4971
1528-0020