Biological Effects of Saponin Fractions from Astragalus verrucosus in Tumor and Non-tumor Human cells

Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cu...

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Bibliographic Details
Published in:Natural product communications 2018-09, Vol.13 (9), p.1934578
Main Authors: Facioni, Maria Sole, Soares, Joana, Adinolfi, Barabara, Gomes, Sara, Raimundo, Liliana, Contini, Adele, Ruffoni, Barbara, Azzarà, Alessia, Tavanti, Arianna, Bertoli, Alessandra, Pistelli, Luisa, Saraiva, Lucilia, Scarpato, Roberto
Format: Article
Language:English
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Summary:Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1801300903