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Effects of Warmed and Humidified CO 2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis
. Pneumoperitoneum insufflation with warmed and humidified carbon dioxide (WH-CO ) can prevent heat loss and increase tissue oxygenation. We evaluated the impact of localized WH-CO insufflation on the anastomotic healing process. . Sixty male Wistar rats were randomized: Group 1 (control, n = 12), G...
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| Published in: | Surgical innovation 2021-02, Vol.28 (1), p.7-17 |
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| creator | Marchegiani, Francesco Noll, Eric Riva, Pietro Kong, Seong-Ho Saccomandi, Paola Vita, Giorgia Lindner, Véronique Namer, Izzie Jacques Marescaux, Jacques Diemunsch, Pierre Diana, Michele |
| description | . Pneumoperitoneum insufflation with warmed and humidified carbon dioxide (WH-CO
) can prevent heat loss and increase tissue oxygenation. We evaluated the impact of localized WH-CO
insufflation on the anastomotic healing process.
. Sixty male Wistar rats were randomized: Group 1 (control, n = 12), Group 2 (cold and dry CO
, CD-CO
, n = 24), and Group 3 (WH-CO
, n = 24). A magnetic compression side-to-side colonic anastomosis was performed under 60-minute local abdominal CO
flow insufflation. Animal temperature was recorded. IL-1, IL-6, and CRP levels were assessed before and after insufflation and on postoperative day (POD) 7 and POD 10. Endoscopic follow-up was performed on POD 7 and POD 10. A burst pressure (BP) test of the specimen was performed on POD 10, and histopathological analysis was then performed. Metabolomics of the anastomotic site was determined.
. Seven rats (5 CD-CO
group, 1 WH-CO
group, and 1 control group) died during the survival period. Necropsies revealed intestinal occlusions (n = 2). One additional rat from the CD-CO
group was sacrificed on POD 7 due to intestinal perforation. The postoperative course was uneventful in the remaining cases. There was no difference in BP among the groups. Thermal monitoring confirmed that WH-CO
insufflation was effective to reduce heat loss. IL-1 levels were statistically and significantly lower on POD 10 in the WH-CO
group than the CD-CO
group but not lower than the control group. CRP levels, histopathology, and metabolomics did not show any difference between the 3 groups.
. WH-CO
was effective to preserve core temperature. However, it did not improve anastomotic healing. |
| doi_str_mv | 10.1177/1553350620967225 |
| format | article |
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) can prevent heat loss and increase tissue oxygenation. We evaluated the impact of localized WH-CO
insufflation on the anastomotic healing process.
. Sixty male Wistar rats were randomized: Group 1 (control, n = 12), Group 2 (cold and dry CO
, CD-CO
, n = 24), and Group 3 (WH-CO
, n = 24). A magnetic compression side-to-side colonic anastomosis was performed under 60-minute local abdominal CO
flow insufflation. Animal temperature was recorded. IL-1, IL-6, and CRP levels were assessed before and after insufflation and on postoperative day (POD) 7 and POD 10. Endoscopic follow-up was performed on POD 7 and POD 10. A burst pressure (BP) test of the specimen was performed on POD 10, and histopathological analysis was then performed. Metabolomics of the anastomotic site was determined.
. Seven rats (5 CD-CO
group, 1 WH-CO
group, and 1 control group) died during the survival period. Necropsies revealed intestinal occlusions (n = 2). One additional rat from the CD-CO
group was sacrificed on POD 7 due to intestinal perforation. The postoperative course was uneventful in the remaining cases. There was no difference in BP among the groups. Thermal monitoring confirmed that WH-CO
insufflation was effective to reduce heat loss. IL-1 levels were statistically and significantly lower on POD 10 in the WH-CO
group than the CD-CO
group but not lower than the control group. CRP levels, histopathology, and metabolomics did not show any difference between the 3 groups.
. WH-CO
was effective to preserve core temperature. However, it did not improve anastomotic healing.</description><identifier>ISSN: 1553-3506</identifier><identifier>EISSN: 1553-3514</identifier><identifier>DOI: 10.1177/1553350620967225</identifier><identifier>PMID: 33095686</identifier><language>eng</language><publisher>United States</publisher><subject>Anastomosis, Surgical ; Animals ; Carbon Dioxide ; Insufflation ; Magnetic Phenomena ; Male ; Models, Theoretical ; Rats ; Rats, Wistar</subject><ispartof>Surgical innovation, 2021-02, Vol.28 (1), p.7-17</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1116-c32656c76731ba7ad3d00677a36e764267f99b327112e661d35bb421ced8c9cf3</citedby><cites>FETCH-LOGICAL-c1116-c32656c76731ba7ad3d00677a36e764267f99b327112e661d35bb421ced8c9cf3</cites><orcidid>0000-0001-5655-6866 ; 0000-0002-1390-8486 ; 0000-0002-5312-8054</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33095686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchegiani, Francesco</creatorcontrib><creatorcontrib>Noll, Eric</creatorcontrib><creatorcontrib>Riva, Pietro</creatorcontrib><creatorcontrib>Kong, Seong-Ho</creatorcontrib><creatorcontrib>Saccomandi, Paola</creatorcontrib><creatorcontrib>Vita, Giorgia</creatorcontrib><creatorcontrib>Lindner, Véronique</creatorcontrib><creatorcontrib>Namer, Izzie Jacques</creatorcontrib><creatorcontrib>Marescaux, Jacques</creatorcontrib><creatorcontrib>Diemunsch, Pierre</creatorcontrib><creatorcontrib>Diana, Michele</creatorcontrib><title>Effects of Warmed and Humidified CO 2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis</title><title>Surgical innovation</title><addtitle>Surg Innov</addtitle><description>. Pneumoperitoneum insufflation with warmed and humidified carbon dioxide (WH-CO
) can prevent heat loss and increase tissue oxygenation. We evaluated the impact of localized WH-CO
insufflation on the anastomotic healing process.
. Sixty male Wistar rats were randomized: Group 1 (control, n = 12), Group 2 (cold and dry CO
, CD-CO
, n = 24), and Group 3 (WH-CO
, n = 24). A magnetic compression side-to-side colonic anastomosis was performed under 60-minute local abdominal CO
flow insufflation. Animal temperature was recorded. IL-1, IL-6, and CRP levels were assessed before and after insufflation and on postoperative day (POD) 7 and POD 10. Endoscopic follow-up was performed on POD 7 and POD 10. A burst pressure (BP) test of the specimen was performed on POD 10, and histopathological analysis was then performed. Metabolomics of the anastomotic site was determined.
. Seven rats (5 CD-CO
group, 1 WH-CO
group, and 1 control group) died during the survival period. Necropsies revealed intestinal occlusions (n = 2). One additional rat from the CD-CO
group was sacrificed on POD 7 due to intestinal perforation. The postoperative course was uneventful in the remaining cases. There was no difference in BP among the groups. Thermal monitoring confirmed that WH-CO
insufflation was effective to reduce heat loss. IL-1 levels were statistically and significantly lower on POD 10 in the WH-CO
group than the CD-CO
group but not lower than the control group. CRP levels, histopathology, and metabolomics did not show any difference between the 3 groups.
. WH-CO
was effective to preserve core temperature. However, it did not improve anastomotic healing.</description><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Carbon Dioxide</subject><subject>Insufflation</subject><subject>Magnetic Phenomena</subject><subject>Male</subject><subject>Models, Theoretical</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1553-3506</issn><issn>1553-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkMtOwzAQRS0EoqWwZ4X8AwE_YrtZVlGhlVq6KIhl5PhRGSV2FScIfoGvxlWhC1YzczVnNDoA3GJ0j7EQD5gxShniBBVcEMLOwPgQZZTh_PzUIz4CVzG-I5QzjNglGFGKCsanfAy-59Ya1UcYLHyTXWs0lF7DxdA67axLY7mBBG6HbueUbODW9QYufRysbWTvgofOQwmfw4dp4PxzbzrXGt-nzXXQKUpn13LnTe8ULEO770yMB6oMTfApm3kZ-9CG6OI1uLCyiebmt07A6-P8pVxkq83TspytMoUx5pmihDOuBBcU11JITTVCXAhJuRE8J1zYoqgpERgTwznWlNV1TrAyeqoKZekEoONd1YUYO2OrfXpadl8VRtVBa_Vfa0Lujsh-qJOiE_Dnkf4AnQhysA</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Marchegiani, Francesco</creator><creator>Noll, Eric</creator><creator>Riva, Pietro</creator><creator>Kong, Seong-Ho</creator><creator>Saccomandi, Paola</creator><creator>Vita, Giorgia</creator><creator>Lindner, Véronique</creator><creator>Namer, Izzie Jacques</creator><creator>Marescaux, Jacques</creator><creator>Diemunsch, Pierre</creator><creator>Diana, Michele</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-5655-6866</orcidid><orcidid>https://orcid.org/0000-0002-1390-8486</orcidid><orcidid>https://orcid.org/0000-0002-5312-8054</orcidid></search><sort><creationdate>202102</creationdate><title>Effects of Warmed and Humidified CO 2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis</title><author>Marchegiani, Francesco ; Noll, Eric ; Riva, Pietro ; Kong, Seong-Ho ; Saccomandi, Paola ; Vita, Giorgia ; Lindner, Véronique ; Namer, Izzie Jacques ; Marescaux, Jacques ; Diemunsch, Pierre ; Diana, Michele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1116-c32656c76731ba7ad3d00677a36e764267f99b327112e661d35bb421ced8c9cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anastomosis, Surgical</topic><topic>Animals</topic><topic>Carbon Dioxide</topic><topic>Insufflation</topic><topic>Magnetic Phenomena</topic><topic>Male</topic><topic>Models, Theoretical</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marchegiani, Francesco</creatorcontrib><creatorcontrib>Noll, Eric</creatorcontrib><creatorcontrib>Riva, Pietro</creatorcontrib><creatorcontrib>Kong, Seong-Ho</creatorcontrib><creatorcontrib>Saccomandi, Paola</creatorcontrib><creatorcontrib>Vita, Giorgia</creatorcontrib><creatorcontrib>Lindner, Véronique</creatorcontrib><creatorcontrib>Namer, Izzie Jacques</creatorcontrib><creatorcontrib>Marescaux, Jacques</creatorcontrib><creatorcontrib>Diemunsch, Pierre</creatorcontrib><creatorcontrib>Diana, Michele</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Surgical innovation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marchegiani, Francesco</au><au>Noll, Eric</au><au>Riva, Pietro</au><au>Kong, Seong-Ho</au><au>Saccomandi, Paola</au><au>Vita, Giorgia</au><au>Lindner, Véronique</au><au>Namer, Izzie Jacques</au><au>Marescaux, Jacques</au><au>Diemunsch, Pierre</au><au>Diana, Michele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Warmed and Humidified CO 2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis</atitle><jtitle>Surgical innovation</jtitle><addtitle>Surg Innov</addtitle><date>2021-02</date><risdate>2021</risdate><volume>28</volume><issue>1</issue><spage>7</spage><epage>17</epage><pages>7-17</pages><issn>1553-3506</issn><eissn>1553-3514</eissn><abstract>. Pneumoperitoneum insufflation with warmed and humidified carbon dioxide (WH-CO
) can prevent heat loss and increase tissue oxygenation. We evaluated the impact of localized WH-CO
insufflation on the anastomotic healing process.
. Sixty male Wistar rats were randomized: Group 1 (control, n = 12), Group 2 (cold and dry CO
, CD-CO
, n = 24), and Group 3 (WH-CO
, n = 24). A magnetic compression side-to-side colonic anastomosis was performed under 60-minute local abdominal CO
flow insufflation. Animal temperature was recorded. IL-1, IL-6, and CRP levels were assessed before and after insufflation and on postoperative day (POD) 7 and POD 10. Endoscopic follow-up was performed on POD 7 and POD 10. A burst pressure (BP) test of the specimen was performed on POD 10, and histopathological analysis was then performed. Metabolomics of the anastomotic site was determined.
. Seven rats (5 CD-CO
group, 1 WH-CO
group, and 1 control group) died during the survival period. Necropsies revealed intestinal occlusions (n = 2). One additional rat from the CD-CO
group was sacrificed on POD 7 due to intestinal perforation. The postoperative course was uneventful in the remaining cases. There was no difference in BP among the groups. Thermal monitoring confirmed that WH-CO
insufflation was effective to reduce heat loss. IL-1 levels were statistically and significantly lower on POD 10 in the WH-CO
group than the CD-CO
group but not lower than the control group. CRP levels, histopathology, and metabolomics did not show any difference between the 3 groups.
. WH-CO
was effective to preserve core temperature. However, it did not improve anastomotic healing.</abstract><cop>United States</cop><pmid>33095686</pmid><doi>10.1177/1553350620967225</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5655-6866</orcidid><orcidid>https://orcid.org/0000-0002-1390-8486</orcidid><orcidid>https://orcid.org/0000-0002-5312-8054</orcidid></addata></record> |
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| source | Sage Journals Online |
| subjects | Anastomosis, Surgical Animals Carbon Dioxide Insufflation Magnetic Phenomena Male Models, Theoretical Rats Rats, Wistar |
| title | Effects of Warmed and Humidified CO 2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis |
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