Phenytoin-Induced Lymphocytic Chemotaxis, Angiogenesis and Accelerated Healing of Decubitus Ulcer in a Patient with Stroke

We studied the effect of topically applied phenytoin on the healing of a decubitus ulcer in the sacral region of an immobile patient with stroke. Another similar, but smaller, ulcer was treated with conventional treatment only and served as a control. The ulcers were measured once a week and biopsie...

Full description

Saved in:
Bibliographic Details
Published in:Journal of international medical research 2004-03, Vol.32 (2), p.201-205
Main Authors: Pitiakoudis, M, Giatromanolaki, A, Iliopoulos, I, Tsaroucha, AK, Simopoulos, C, Piperidou, C
Format: Article
Language:English
Subjects:
Chemotaxis, Leukocyte - drug effects
Humans
Immunohistochemistry
Male
Middle Aged
Neovascularization, Physiologic - drug effects
Phenytoin - adverse effects
Phenytoin - pharmacology
Phenytoin - therapeutic use
Pressure Ulcer - physiopathology
Pressure Ulcer - therapy
Wound Healing - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effect of topically applied phenytoin on the healing of a decubitus ulcer in the sacral region of an immobile patient with stroke. Another similar, but smaller, ulcer was treated with conventional treatment only and served as a control. The ulcers were measured once a week and biopsies were taken from the margins before, 1 week and 2 weeks after commencing treatment with phenytoin. Clinically, phenytoin substantially accelerated the rate of healing. Microscopic examination of the biopsies showed increased lymphocytic infiltration of the phenytointreated lesion. Anti-CD31 immunohistochemistry revealed dense CD31+ lymphocytic infiltration and increased angiogenesis only in the phenytointreated lesion. Our findings suggest that phenytoin enhances wound healing by stimulating lymphocytic chemotaxis and up-regulation of angiogenesis.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000403200213