A Pathology Review of the Lower Gastrointestinal Tract in Relation to Ulcerative Colitis in Rats and Cynomolgus Macaques Treated With Ammonium Perfluorooctanoate

Among many short-term, subchronic, and chronic toxicology studies with ammonium perfluorooctanoate (PFOA), the gastrointestinal tract has not been identified as a target organ for PFOA-related toxicity in laboratory animals where the corresponding serum PFOA concentrations typically approach several...

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Bibliographic Details
Published in:Toxicologic pathology 2020-06, Vol.48 (4), p.593-602
Main Authors: Chang, Sue, Parker, George A., Kleinschmidt, Sarah E., Olsen, Geary W., Ley, Carol A., Taiwo, Oyebode A.
Format: Article
Language:English
Subjects:
Animals
Caprylates - toxicity
Colitis, Ulcerative
Disease Models, Animal
Female
Fluorocarbons - toxicity
Humans
Lower Gastrointestinal Tract - pathology
Macaca fascicularis
Male
Ohio
Rats
Rats, Sprague-Dawley
Rivers
Toxicity Tests
Water Pollutants, Chemical - toxicity
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Summary:Among many short-term, subchronic, and chronic toxicology studies with ammonium perfluorooctanoate (PFOA), the gastrointestinal tract has not been identified as a target organ for PFOA-related toxicity in laboratory animals where the corresponding serum PFOA concentrations typically approach several orders of magnitude higher than the general human population. These lack of gastrointestinal tract-related findings were in direct contrast to an epidemiological observation where a positive trend was observed for ulcerative colitis, an idiopathic chronic inflammatory condition of the gut, in a Mid-Ohio River community whose drinking water contained higher levels of PFOA. This study was conducted to perform a histological reevaluation of large intestine sections in laboratory animals from 2 long-term toxicological studies: one was with Sprague Dawley rats that received ammonium PFOA in their diet for 2 years and the other one was with cynomolgus macaques that received daily capsules of ammonium PFOA for 6 months. In both studies, there was a lack of histological evidence of treatment-related inflammatory lesions that was suggestive of the occurrence of ulcerative colitis in these laboratory animals even under the most rigorous treatment schedules. These findings do not offer support for the biological plausibility of the epidemiological associations reported.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623320911606