Adrenomedullin Receptor Expression in Human Lung and in Pulmonary Tumors

Adrenomedullin (AM) is a multifunctional regulatory peptide that stimulates cyclic AMP production in many target tissues and is highly expressed in the lung. Analysis of the distribution of the recently cloned AM receptor (AM-R) by non-radioactive in situ hybridization revealed abundant expression i...

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Bibliographic Details
Published in:The journal of histochemistry and cytochemistry 1997-02, Vol.45 (2), p.159-164
Main Authors: Martinez, Alfredo, Miller, Mae Jean, Catt, Kevin J, Cuttitta, Frank
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Animals
Blotting, Southern
Carcinoma, Large Cell - metabolism
Carcinoma, Small Cell - metabolism
Carcinoma, Squamous Cell - metabolism
GTP-Binding Proteins - metabolism
Humans
In Situ Hybridization
Lung - metabolism
Lung Neoplasms - metabolism
Membrane Proteins - metabolism
Polymerase Chain Reaction
Rats
Receptors, Adrenomedullin
Receptors, Peptide
Tumor Cells, Cultured
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Summary:Adrenomedullin (AM) is a multifunctional regulatory peptide that stimulates cyclic AMP production in many target tissues and is highly expressed in the lung. Analysis of the distribution of the recently cloned AM receptor (AM-R) by non-radioactive in situ hybridization revealed abundant expression in the basal cells of the airway epithelium and Type II pneumocytes. The expression of AM-R in the two cell types involved in epithelial regeneration of the lung suggests that AM may be relevant in such functions as organ development, wound repair, and epithelial turnover. AM-Rs are also synthesized in vivo and in vitro by a variety of tumor cells that also express the ligand, suggesting the existence of an autocrine loop that may be involved in tumor growth stimulation. The present findings suggest that the AM/AM-R regulatory system plays a major role in respiratory physiology and lung carcinogenesis and that new functions for AM remain to be identified.
ISSN:0022-1554
1551-5044
DOI:10.1177/002215549704500202