Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase

SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical ap...

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Published in:The journal of histochemistry and cytochemistry 2001-02, Vol.49 (2), p.209-217
Main Authors: Andrés, Noemí, Lizcano, José Miguel, Rodríguez, Manuel J., Romera, Manuel, Unzeta, Mercedes, Mahy, Nicole
Format: Article
Language:English
Subjects:
Amine Oxidase (Copper-Containing) - antagonists & inhibitors
Amine Oxidase (Copper-Containing) - metabolism
Cell Line
Enzyme Inhibitors - pharmacology
Humans
Immunoblotting
Immunohistochemistry
Organ Specificity
Semicarbazides - pharmacology
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Summary:SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical approach to examine the cellular localization of SSAO in human peripheral tissues (adrenal gland, duodenum, heart, kidney, lung, liver, pancreas, spleen, thyroid gland, and blood vessels) and also analyzed its subcellular localization. The results are in agreement with the specific activities also determined in the same samples and are discussed with reference to the tissue distribution of monoamine oxidase A and B. Together with the oxidative deamination of monoamines, SSAO cellular localization indicates that, in most human peripheral tissues, it might participate in the regulation of physiological processes via H2O2 generation. (J Histochem Cytochem 49:209–217, 2001)
ISSN:0022-1554
1551-5044
DOI:10.1177/002215540104900208