Effects of Nilvadipine on Cerebral Blood Flow in Patients With Alzheimer Disease: A Randomized Trial

Cerebrovascular changes, including reduced cerebral blood flow (CBF), occur early in the development of Alzheimer disease and may accelerate disease progression. This randomized, double-blind, placebo-controlled study investigated how 6 months of treatment with the calcium antagonist nilvadipine wou...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2019-08, Vol.74 (2), p.413-420
Main Authors: de Jong, Daan L.K, de Heus, Rianne A.A, Rijpma, Anne, Donders, Rogier, Olde Rikkert, Marcel G.M, Günther, Matthias, Lawlor, Brian A, van Osch, Matthias J.P, Claassen, Jurgen A.H.R
Format: Article
Language:English
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Summary:Cerebrovascular changes, including reduced cerebral blood flow (CBF), occur early in the development of Alzheimer disease and may accelerate disease progression. This randomized, double-blind, placebo-controlled study investigated how 6 months of treatment with the calcium antagonist nilvadipine would affect CBF in patients with mild-to-moderate Alzheimer disease. CBF was measured with magnetic resonance arterial spin labeling in whole-brain gray matter and in a priori defined regions of interest including the hippocampus. Fifty-eight patients were randomly assigned (29 in each group), of whom 22 in both groups had no magnetic resonance exclusion criteria and were medication compliant over 6 months. Mean age was 72.8±6.2 years, mean mini-mental state examination was 20.4±3.4. Nilvadipine treatment lowered systolic blood pressure (Δ=−11.5 [95% CI, −19.7 to −3.2] mm Hg; P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.119.12892