Case Report: Three Case Reports of Rapidly Progressive Dementias and Narrative Review

Rapidly progressive dementia (RPD) is a heterogeneous group of diseases characterized by cognitive impairment and other neurological disorders developed in a short span of fewer than 2 years. Currently viewed as new and infrequent entities, most medical personnel have little understanding of it. Nev...

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Published in:Case reports in neurology 2022-09, Vol.14 (3), p.441-455
Main Authors: Clavijo, Carlos Andrés, Portilla Buenaventura, Ana María, Benavides Albornoz, Galo Santiago, Muñoz Cabrera, Juan José, Murillo Reyes, María Camila, Chauvez Gallego, Alejandra, Hurtado González, Carlos Alberto, Ospina Otalvaro, Sebastian, Marmolejo Escobar, Carlos Steven, Quebrada Mera, Karen Julieth, Lenis, Paola Andrea Gutiérrez, Arango García, Lina María, Lucumí, Armando
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antibodies
Autoimmune diseases
Case reports
Case Series - General Neurology
Convulsions & seizures
Creutzfeldt-Jakob disease
Dementia
Encephalitis
Etiology
Hallucinations
Memory
Morphology
nmdar
Patients
Potassium
Proteins
rapidly progressive dementia
voltage-gated potassium channel complex
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Summary:Rapidly progressive dementia (RPD) is a heterogeneous group of diseases characterized by cognitive impairment and other neurological disorders developed in a short span of fewer than 2 years. Currently viewed as new and infrequent entities, most medical personnel have little understanding of it. Nevertheless, they significantly compromise many patients’ quality of life. Here, we drive 3 clinical cases that evolve as RPD with different etiologies. Case 1:70-year-old woman presented to the emergency with neuropsychiatric syndrome for 18 days. The researchers identified inflammatory cerebrospinal fluid (CSF), protein 14-3-3-positive T-tau protein, MRI: T2 and FLAIR hyperintensities in bilateral caudate nuclei with diffusion restriction, EEG shows a generalized periodic pattern with triphasic wave morphology. Case 2:29-year-old man with cognitive impairment and faciobrachial dystonia seizure. The diagnosis was confirmed by achieving elevated antibodies against voltage-gated potassium channels. Case 3:A 49-year-old woman with encephalopathy and myoclonic seizures; EEG and MRI showed subtle changes. The patient also had a normal CSF but a positive CBA serologic NMDA-R antibody test. We described fundamental aspects of RPD to allow made differential diagnoses in patients with cognitive impairment and encephalopathy. Establishing an early and accurate diagnosis can benefit patients with RPD etiologies that are treatable and even reversible, decreasing in morbidity and mortality.
ISSN:1662-680X
1662-680X
DOI:10.1159/000525701