Acute Abdomen with Ileus: A Heralding Presentation of Neuroleptic Malignant Syndrome

The pathophysiology of neuroleptic malignant syndrome (NMS) with use of psychotropic drugs is still unclear. Although a rare event with an incidence of 0.02–3.2%, when not promptly recognized and managed, it carries a high mortality (10–20%) and morbidity rate. Presentation can be either typical, wi...

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Bibliographic Details
Published in:Case reports in gastroenterology 2018-09, Vol.12 (3), p.566-569
Main Authors: Chime, Chukwunonso, Alemam, Ahmed, Kumar, Kishore, Dhallu, Manjeet
Format: Article
Language:English
Subjects:
Abdomen
Acute abdomen
Blood pressure
Cardiology
Case reports
Dopamine
Drug dosages
Etiology
Fever
Heart rate
Hyperactivity
Ileus
Infectious diseases
Laboratories
Mental disorders
Metabolism
Mortality
Neuroleptic malignant syndrome
Patients
Psychotropic drugs
Schizophrenia
Single Case
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Summary:The pathophysiology of neuroleptic malignant syndrome (NMS) with use of psychotropic drugs is still unclear. Although a rare event with an incidence of 0.02–3.2%, when not promptly recognized and managed, it carries a high mortality (10–20%) and morbidity rate. Presentation can be either typical, with muscle rigidity and hyperpyrexia, or atypical, the latter posing diagnostic and early management challenges in clinical practice. Our patient presented with delayed fever and ileus, making early diagnosis difficult. We propose that NMS be considered an alternate diagnosis in patients using psychotropic medications and manifest ileus and delayed fever, especially after other differentials have been excluded.
ISSN:1662-0631
1662-0631
DOI:10.1159/000492460