Association between Cognitive Impairment and Gait Disturbance in Patients with Idiopathic Normal Pressure Hydrocephalus

We compared the scores of the Frontal Assessment Battery (FAB), initial fluency subtest, category fluency subtest and subtests of the Mini-Mental State Examination (MMSE) between patients with idiopathic normal pressure hydrocephalus (iNPH) and age-, sex- and MMSE-matched patients with Alzheimer’s d...

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Bibliographic Details
Published in:Dementia and geriatric cognitive disorders 2005-01, Vol.20 (2-3), p.71-76
Main Authors: Miyoshi, Noriko, Kazui, Hiroaki, Ogino, Atsushi, Ishikawa, Masatsune, Miyake, Hiroji, Tokunaga, Hiromasa, Ikejiri, Yoshitaka, Takeda, Masatoshi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - psychology
Biological and medical sciences
Cognition Disorders - etiology
Cognition Disorders - psychology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Gait
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - psychology
Humans
Hydrocephalus, Normal Pressure - complications
Hydrocephalus, Normal Pressure - psychology
Injuries of the limb. Injuries of the spine
Male
Medical sciences
Middle Aged
Neurology
Neuropharmacology
Neuropsychological Tests
Original Research Article
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Traumas. Diseases due to physical agents
Verbal Behavior
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Summary:We compared the scores of the Frontal Assessment Battery (FAB), initial fluency subtest, category fluency subtest and subtests of the Mini-Mental State Examination (MMSE) between patients with idiopathic normal pressure hydrocephalus (iNPH) and age-, sex- and MMSE-matched patients with Alzheimer’s disease (AD). In patients with iNPH, the time and number of steps required to go and come back a 10-meter distance were measured (Walking test) and the associations between the scores of the cognitive tests and the performance of the Walking test were evaluated. The scores of the FAB and initial fluency subtest in patients with iNPH were significantly lower than those in patients with AD. The scores of the FAB, initial fluency subtest and serial 7 subtest of the MMSE significantly correlated with the two scores of the Walking test in patients with iNPH. The present results indicate that frontal lobe functions were impaired in patients with iNPH and that cognitive impairment was closely associated with gait disturbance in patients with iNPH.
ISSN:1420-8008
1421-9824
DOI:10.1159/000085858